Does heart surgery change the capacity of α1-antitrypsin to inhibit the ATP-induced release of monocytic interleukin-1β? A preliminary study

•Patient α1-antitrypsin inhibits ATP-mediated release of monocytic interleukin-1β.•Heart surgery does not markedly reduce this activity of alpha1-antitrypsin.•The anti-elastase function of α1-antitrypsin is unimpaired by heart surgery. Heart surgery involving cardiopulmonary bypass induces systemic...

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Veröffentlicht in:	International immunopharmacology 2020-04, Vol.81, p.106297-106297, Article 106297
Hauptverfasser:	Agné, A., Richter, K., Tumpara, S., Sauer, A.-L., Beckert, F., Wrenger, S., Zakrzewicz, A., Hecker, A., Markmann, M., Koch, C., Zajonz, T., Sander, M., Böning, A., Padberg, W., Janciauskiene, S., Grau, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	A1-antitrypsin Acetylcholine receptors (nicotinic) Adenosine Triphosphate - metabolism Aged alpha 1-Antitrypsin - metabolism ATP Blood plasma Cardiopulmonary Bypass Complex formation Cytokines Elastase Female Heart Heart surgery Humans IL-1β In vivo methods and tests Inflammasome Inflammation Inflammation - etiology Inflammation - immunology Inflammatory response Interleukin-1beta - metabolism Interleukins Leukocyte Elastase - metabolism Leukocytes (neutrophilic) Lipopolysaccharides Lipopolysaccharides - metabolism Male Metabotropic receptors Middle Aged Monocytes Monocytes - physiology Neutrophils Pathogenesis Pilot Projects Postoperative Complications - immunology Prospective Studies Protease Proteinase Proteinase inhibitors SERPINA1 Surgery Systemic inflammation U937 Cells
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