Novel Anticoagulant Peptide from Lactoferrin Binding Thrombin at the Active Site and Exosite‑I

Thrombin is currently one of the important targets for the treatment and prevention of thrombosis. At present, there are few reports on the application of lactoferrin peptides in anticoagulation. In this study, a peptide with the amino acid sequence of LRPVAAEIY (LF-LR) derived from lactoferrin was...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2020-03, Vol.68 (10), p.3132-3139
Hauptverfasser:	Xu, Shiqi, Fan, Fengjiao, Liu, Hanxiong, Cheng, Shuzhen, Tu, Maolin, Du, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anticoagulants - chemistry Binding Sites Catalytic Domain Cattle Fibrinogen - chemistry Humans Kinetics Lactoferrin - chemistry Molecular Docking Simulation Peptides - chemistry Protein Binding Thrombin - chemistry Thrombin Time
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