Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure
Purpose To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG). Study design Retrospective comparative study. Methods POAG patients meeting th...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2020-05, Vol.64 (3), p.278-284 |
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| creator | Ha, Ahnul Kim, Tai Jun Lee, Won June Kim, Dong Myung Jeoung, Jin Wook Kim, Young Kook Park, Ki Ho |
| description | Purpose
To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).
Study design
Retrospective comparative study.
Methods
POAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Defects’ approximations to the macula (angle α) and width (angle ß) as well as the angle between the disc long axis and the vertical meridian line (angle Ɣ) were measured on red-free fundus photography. The corrected angle α was calculated as the difference between angles α and Ɣ. The defect area’s RNFL thickness was calculated by means of optical coherence tomography’s Advanced Extraction analysis utility.
Results
Comparative analysis was performed between 2 groups: 45 eyes of 45 patients with low-teen IOP (group A: highest IOP ≤ 15 mmHg) and 49 eyes of 49 patients with high-teen IOP (group B: lowest IOP > 15 mmHg). In group A, the mean baseline IOP was lower (12.9 ± 1.3 vs 17.1 ± 1.0 mmHg;
P
< .001), the corrected angle α was smaller (32.4 ± 15.1 vs 39.5 ± 13.1 degrees;
P
= .017), and the defect area’s RNFL thickness was thinner (66.3 ± 16.8 vs 76.3 ± 14.9 μm;
P
= .003) than in group B; angle ß showed no intergroup difference (
P
= .230).
Conclusions
In POAG patients with low-teen IOP relative to those with high-teen IOP, localized RNFL defects were closer to the macula. In addition, the RNFL thickness of the defect area was markedly thinner. |
| doi_str_mv | 10.1007/s10384-019-00704-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2356584885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2404055930</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-8096649f9c42179f77c912840badfb6d9c53e20e1b25491b3d70c934aa09dcf73</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7rj6BzxIwIuXuJWv7s5RFr9gQRZ2zyGdroxZ0ukx6XaZf290VgUPXhKKeuqtkIeQlxzecoD-onKQg2LADWslKKYekR3vuGRCqO4x2QEIzjTX-ow8q_UOAJSQ4ik5kwI6MSizI_fXm8trXN0avyN12aVjjZUugRZcYytpxtI6IY5YaHLHdk4Y0K80ZoqupCNdDpiZy_uEdJ_c5pfZ0fu4fqV5KXNLiHktbvFbcoUeCta6FXxOngSXKr54uM_J7Yf3N5ef2NWXj58v310xL41Z2QCm65QJxivBexP63hveXg6jm8LYTcZriQKQj0Irw0c59eCNVM6BmXzo5Tl5c8o9lOXbhnW1c6weU3IZl61aIXWnBzUMuqGv_0Hvlq20L2iUAgVaGwmNEifKl6XWgsEeSpxdOVoO9qcWe9Jimxb7S4tVbejVQ_Q2zjj9GfntoQHyBNTWynssf3f_J_YHAciZJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2404055930</pqid></control><display><type>article</type><title>Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure</title><source>MEDLINE</source><source>SpringerLink</source><creator>Ha, Ahnul ; Kim, Tai Jun ; Lee, Won June ; Kim, Dong Myung ; Jeoung, Jin Wook ; Kim, Young Kook ; Park, Ki Ho</creator><creatorcontrib>Ha, Ahnul ; Kim, Tai Jun ; Lee, Won June ; Kim, Dong Myung ; Jeoung, Jin Wook ; Kim, Young Kook ; Park, Ki Ho</creatorcontrib><description>Purpose
To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).
Study design
Retrospective comparative study.
Methods
POAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Defects’ approximations to the macula (angle α) and width (angle ß) as well as the angle between the disc long axis and the vertical meridian line (angle Ɣ) were measured on red-free fundus photography. The corrected angle α was calculated as the difference between angles α and Ɣ. The defect area’s RNFL thickness was calculated by means of optical coherence tomography’s Advanced Extraction analysis utility.
Results
Comparative analysis was performed between 2 groups: 45 eyes of 45 patients with low-teen IOP (group A: highest IOP ≤ 15 mmHg) and 49 eyes of 49 patients with high-teen IOP (group B: lowest IOP > 15 mmHg). In group A, the mean baseline IOP was lower (12.9 ± 1.3 vs 17.1 ± 1.0 mmHg;
P
< .001), the corrected angle α was smaller (32.4 ± 15.1 vs 39.5 ± 13.1 degrees;
P
= .017), and the defect area’s RNFL thickness was thinner (66.3 ± 16.8 vs 76.3 ± 14.9 μm;
P
= .003) than in group B; angle ß showed no intergroup difference (
P
= .230).
Conclusions
In POAG patients with low-teen IOP relative to those with high-teen IOP, localized RNFL defects were closer to the macula. In addition, the RNFL thickness of the defect area was markedly thinner.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-019-00704-4</identifier><identifier>PMID: 32062849</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Clinical Investigation ; Comparative analysis ; Comparative studies ; Defects ; Diurnal ; Eye (anatomy) ; Female ; Glaucoma ; Glaucoma, Open-Angle - diagnostic imaging ; Glaucoma, Open-Angle - pathology ; Humans ; Intraocular pressure ; Intraocular Pressure - physiology ; Male ; Mathematical analysis ; Medicine ; Medicine & Public Health ; Middle Aged ; Nerve Fibers - pathology ; Ophthalmology ; Optic Nerve Diseases - diagnostic imaging ; Optic Nerve Diseases - pathology ; Optical Coherence Tomography ; Photography ; Pressure ; Quantitative analysis ; Retina ; Retinal Ganglion Cells - pathology ; Retrospective Studies ; Thickness ; Tomography, Optical Coherence ; Tonometry, Ocular ; Vision Disorders - physiopathology ; Visual field ; Visual Field Tests ; Visual fields ; Visual Fields - physiology ; Visual observation</subject><ispartof>Japanese journal of ophthalmology, 2020-05, Vol.64 (3), p.278-284</ispartof><rights>Japanese Ophthalmological Society 2020</rights><rights>Japanese Ophthalmological Society 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-8096649f9c42179f77c912840badfb6d9c53e20e1b25491b3d70c934aa09dcf73</citedby><cites>FETCH-LOGICAL-c399t-8096649f9c42179f77c912840badfb6d9c53e20e1b25491b3d70c934aa09dcf73</cites><orcidid>0000-0002-8137-8843</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-019-00704-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-019-00704-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32062849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ha, Ahnul</creatorcontrib><creatorcontrib>Kim, Tai Jun</creatorcontrib><creatorcontrib>Lee, Won June</creatorcontrib><creatorcontrib>Kim, Dong Myung</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><title>Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).
Study design
Retrospective comparative study.
Methods
POAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Defects’ approximations to the macula (angle α) and width (angle ß) as well as the angle between the disc long axis and the vertical meridian line (angle Ɣ) were measured on red-free fundus photography. The corrected angle α was calculated as the difference between angles α and Ɣ. The defect area’s RNFL thickness was calculated by means of optical coherence tomography’s Advanced Extraction analysis utility.
Results
Comparative analysis was performed between 2 groups: 45 eyes of 45 patients with low-teen IOP (group A: highest IOP ≤ 15 mmHg) and 49 eyes of 49 patients with high-teen IOP (group B: lowest IOP > 15 mmHg). In group A, the mean baseline IOP was lower (12.9 ± 1.3 vs 17.1 ± 1.0 mmHg;
P
< .001), the corrected angle α was smaller (32.4 ± 15.1 vs 39.5 ± 13.1 degrees;
P
= .017), and the defect area’s RNFL thickness was thinner (66.3 ± 16.8 vs 76.3 ± 14.9 μm;
P
= .003) than in group B; angle ß showed no intergroup difference (
P
= .230).
Conclusions
In POAG patients with low-teen IOP relative to those with high-teen IOP, localized RNFL defects were closer to the macula. In addition, the RNFL thickness of the defect area was markedly thinner.</description><subject>Adult</subject><subject>Clinical Investigation</subject><subject>Comparative analysis</subject><subject>Comparative studies</subject><subject>Defects</subject><subject>Diurnal</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - diagnostic imaging</subject><subject>Glaucoma, Open-Angle - pathology</subject><subject>Humans</subject><subject>Intraocular pressure</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Optic Nerve Diseases - diagnostic imaging</subject><subject>Optic Nerve Diseases - pathology</subject><subject>Optical Coherence Tomography</subject><subject>Photography</subject><subject>Pressure</subject><subject>Quantitative analysis</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retrospective Studies</subject><subject>Thickness</subject><subject>Tomography, Optical Coherence</subject><subject>Tonometry, Ocular</subject><subject>Vision Disorders - physiopathology</subject><subject>Visual field</subject><subject>Visual Field Tests</subject><subject>Visual fields</subject><subject>Visual Fields - physiology</subject><subject>Visual observation</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6BzxIwIuXuJWv7s5RFr9gQRZ2zyGdroxZ0ukx6XaZf290VgUPXhKKeuqtkIeQlxzecoD-onKQg2LADWslKKYekR3vuGRCqO4x2QEIzjTX-ow8q_UOAJSQ4ik5kwI6MSizI_fXm8trXN0avyN12aVjjZUugRZcYytpxtI6IY5YaHLHdk4Y0K80ZoqupCNdDpiZy_uEdJ_c5pfZ0fu4fqV5KXNLiHktbvFbcoUeCta6FXxOngSXKr54uM_J7Yf3N5ef2NWXj58v310xL41Z2QCm65QJxivBexP63hveXg6jm8LYTcZriQKQj0Irw0c59eCNVM6BmXzo5Tl5c8o9lOXbhnW1c6weU3IZl61aIXWnBzUMuqGv_0Hvlq20L2iUAgVaGwmNEifKl6XWgsEeSpxdOVoO9qcWe9Jimxb7S4tVbejVQ_Q2zjj9GfntoQHyBNTWynssf3f_J_YHAciZJg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Ha, Ahnul</creator><creator>Kim, Tai Jun</creator><creator>Lee, Won June</creator><creator>Kim, Dong Myung</creator><creator>Jeoung, Jin Wook</creator><creator>Kim, Young Kook</creator><creator>Park, Ki Ho</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8137-8843</orcidid></search><sort><creationdate>20200501</creationdate><title>Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure</title><author>Ha, Ahnul ; Kim, Tai Jun ; Lee, Won June ; Kim, Dong Myung ; Jeoung, Jin Wook ; Kim, Young Kook ; Park, Ki Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-8096649f9c42179f77c912840badfb6d9c53e20e1b25491b3d70c934aa09dcf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Clinical Investigation</topic><topic>Comparative analysis</topic><topic>Comparative studies</topic><topic>Defects</topic><topic>Diurnal</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - diagnostic imaging</topic><topic>Glaucoma, Open-Angle - pathology</topic><topic>Humans</topic><topic>Intraocular pressure</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Mathematical analysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Optic Nerve Diseases - diagnostic imaging</topic><topic>Optic Nerve Diseases - pathology</topic><topic>Optical Coherence Tomography</topic><topic>Photography</topic><topic>Pressure</topic><topic>Quantitative analysis</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retrospective Studies</topic><topic>Thickness</topic><topic>Tomography, Optical Coherence</topic><topic>Tonometry, Ocular</topic><topic>Vision Disorders - physiopathology</topic><topic>Visual field</topic><topic>Visual Field Tests</topic><topic>Visual fields</topic><topic>Visual Fields - physiology</topic><topic>Visual observation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ha, Ahnul</creatorcontrib><creatorcontrib>Kim, Tai Jun</creatorcontrib><creatorcontrib>Lee, Won June</creatorcontrib><creatorcontrib>Kim, Dong Myung</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ha, Ahnul</au><au>Kim, Tai Jun</au><au>Lee, Won June</au><au>Kim, Dong Myung</au><au>Jeoung, Jin Wook</au><au>Kim, Young Kook</au><au>Park, Ki Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>64</volume><issue>3</issue><spage>278</spage><epage>284</epage><pages>278-284</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).
Study design
Retrospective comparative study.
Methods
POAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Defects’ approximations to the macula (angle α) and width (angle ß) as well as the angle between the disc long axis and the vertical meridian line (angle Ɣ) were measured on red-free fundus photography. The corrected angle α was calculated as the difference between angles α and Ɣ. The defect area’s RNFL thickness was calculated by means of optical coherence tomography’s Advanced Extraction analysis utility.
Results
Comparative analysis was performed between 2 groups: 45 eyes of 45 patients with low-teen IOP (group A: highest IOP ≤ 15 mmHg) and 49 eyes of 49 patients with high-teen IOP (group B: lowest IOP > 15 mmHg). In group A, the mean baseline IOP was lower (12.9 ± 1.3 vs 17.1 ± 1.0 mmHg;
P
< .001), the corrected angle α was smaller (32.4 ± 15.1 vs 39.5 ± 13.1 degrees;
P
= .017), and the defect area’s RNFL thickness was thinner (66.3 ± 16.8 vs 76.3 ± 14.9 μm;
P
= .003) than in group B; angle ß showed no intergroup difference (
P
= .230).
Conclusions
In POAG patients with low-teen IOP relative to those with high-teen IOP, localized RNFL defects were closer to the macula. In addition, the RNFL thickness of the defect area was markedly thinner.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>32062849</pmid><doi>10.1007/s10384-019-00704-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8137-8843</orcidid></addata></record> |
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| subjects | Adult Clinical Investigation Comparative analysis Comparative studies Defects Diurnal Eye (anatomy) Female Glaucoma Glaucoma, Open-Angle - diagnostic imaging Glaucoma, Open-Angle - pathology Humans Intraocular pressure Intraocular Pressure - physiology Male Mathematical analysis Medicine Medicine & Public Health Middle Aged Nerve Fibers - pathology Ophthalmology Optic Nerve Diseases - diagnostic imaging Optic Nerve Diseases - pathology Optical Coherence Tomography Photography Pressure Quantitative analysis Retina Retinal Ganglion Cells - pathology Retrospective Studies Thickness Tomography, Optical Coherence Tonometry, Ocular Vision Disorders - physiopathology Visual field Visual Field Tests Visual fields Visual Fields - physiology Visual observation |
| title | Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure |
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