Application of a digital PCR method for WT1 to myeloid neoplasms in CR and deep ELN WT1 molecular response (< 10 copies)

Bone marrow WT1 mRNA levels assessed by the ELN method are useful to establish prognostic correlations in myeloid malignancies treated with chemotherapy or hematopoietic stem cell transplantation (HCT). Those patients with WT1 levels below ten copies have a good outcome. However, some of these patie...

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Veröffentlicht in:	Annals of hematology 2020-04, Vol.99 (4), p.765-772
Hauptverfasser:	Bussaglia, E., Pratcorona, M., Carricondo, M., Sansegundo, L., Rubio, M. A., Monter, A., Brell, A., Badell, I., Esteve, J., Arnan, M., Talarn, C., Tormo, M., García, A., Vall-Llovera, F., Ortin, X., Pedro, C., Bargay, J., Brunet, S., Sierra, J., Nomdedéu, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Chemotherapy DNA, Complementary - genetics Female Flow Cytometry Gene Dosage Gene expression Genes, Wilms Tumor Hematology Humans Immunophenotyping Infant Kaplan-Meier Estimate Leukemia, Myeloid, Acute - genetics Male Medicine Medicine & Public Health Middle Aged Myelodysplastic Syndromes - genetics Oncology Original Article Polymerase Chain Reaction - methods Prognosis Real-Time Polymerase Chain Reaction RNA, Neoplasm - genetics Stem cell transplantation Survival analysis Young Adult
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