Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success

The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but the successful clinical development of targeted therapies has only recently been realized. This Perspective traces the decades long evolution of medicinal chemistry required t...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-07, Vol.63 (13), p.6600-6623
Hauptverfasser:	Dubowchik, Gene M, Conway, Charles M, Xin, Alison W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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