Structural Feature of Lipid Scrambling Model Transmembrane Peptides: Same-Side Positioning of Hydrophilic Residues and Their Deeper Position

Phospholipid scramblases that catalyze lipid transbilayer movement are associated with intercellular signaling and lipid homeostasis. Although several studies have shown that the hydrophilic residue-rich groove of the proteins mediates lipid scrambling, the interactions between the groove and the li...

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Veröffentlicht in:	The journal of physical chemistry letters 2020-03, Vol.11 (5), p.1662-1667
Hauptverfasser:	Nakao, Hiroyuki, Sugimoto, Yuta, Ikeda, Keisuke, Saito, Hiroaki, Nakano, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Hydrophobic and Hydrophilic Interactions Molecular Dynamics Simulation Peptides - chemistry Peptides - metabolism Phospholipids - chemistry Phospholipids - metabolism Unilamellar Liposomes - chemistry Unilamellar Liposomes - metabolism
Online-Zugang:	Volltext
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