MLL1 combined with GSK3 and MAP2K inhibition improves the development of in vitro-fertilized embryos

The MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity. The inhibition of the FGFR signaling pathway and activation of the WNT pathway by small mole...

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Veröffentlicht in:	Theriogenology 2020-04, Vol.146, p.58-70
Hauptverfasser:	Han, Xuejie, Xiang, Jinzhu, Li, Chen, Wang, Jing, Wang, Chen, Zhang, Yuanyuan, Li, Zihong, Lu, Zhenyu, Yue, Yongli, Li, Xueling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle DNA methyltransferase Embryo Culture Techniques - veterinary Female Fertilization in Vitro - veterinary Gene Expression Regulation, Developmental Glycogen Synthase Kinase 3 - antagonists & inhibitors GSK3 Histone-Lysine N-Methyltransferase - antagonists & inhibitors MAP2K Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors MLL1 MM-102 Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - metabolism
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