Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

[Display omitted] •Novel 5,6,7-trimethoxy flavonoid salicylate derivatives were synthesized and characterized.•Compound 7f exhibited potent anti-tumor activity in vitro.•Compound 7f was effective in reducing the stability of microtubule cytoskeleton.•Docking studies mimicked the possible binding mec...

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Veröffentlicht in:	Bioorganic chemistry 2020-03, Vol.96, p.103652-103652, Article 103652
Hauptverfasser:	Liu, Renbo, Deng, Xiangping, Peng, Yijiao, Feng, Wanshi, Xiong, Runde, Zou, Yang, Lei, Xiaoyong, Zheng, Xing, Xie, Zhizhong, Tang, Guotao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-tumor Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor Flavonoid Flavonoids - chemical synthesis Flavonoids - chemistry Flavonoids - pharmacology Glycolysis HIF-1α Humans Microtubules Molecular Docking Simulation Neoplasms - drug therapy Neoplasms - metabolism Salicylates - chemical synthesis Salicylates - chemistry Salicylates - pharmacology Tubulin - metabolism
Online-Zugang:	Volltext
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