Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes
To describe the epidemiology of health status, impairments, activities and participation in adults with cerebral palsy (CP). Embase, MEDLINE, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane, and Google Scholar were searched for 3 themes (“cerebral palsy,” “adult,” a...
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| Veröffentlicht in: | Archives of physical medicine and rehabilitation 2020-06, Vol.101 (6), p.1041-1052 |
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| creator | van Gorp, Marloes Hilberink, Sander R. Noten, Suzie Benner, Joyce L. Stam, Henk J. van der Slot, Wilma M.A. Roebroeck, Marij E. |
| description | To describe the epidemiology of health status, impairments, activities and participation in adults with cerebral palsy (CP).
Embase, MEDLINE, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane, and Google Scholar were searched for 3 themes (“cerebral palsy,” “adult,” and “outcome assessment”) in literature published between January 2000 and December 2018.
Full-article peer-reviewed English journal articles on descriptive, observational, or experimental studies describing the most studied outcomes in adults with CP (n≥25, age≥18y) were included. Studies were included in the analyses if frequently studied outcomes were described in at least 3 studies using similar methods of assessment.
Data were extracted independently by 2 authors from 65 articles (total N=28,429) using a standardized score sheet.
Meta-analyses revealed that overall, on average 65.1% (95% confidence interval [CI], 55.1-74.5) of adults with CP experienced pain, 57.9% (95% CI, 51.1-64.6) were ambulant, 65.5% (95% CI, 61.2-69.7) had little or no limitation in manual ability, 18.2% (95% CI, 10.6-27.2) had tertiary education, 39.2% (95% CI, 31.5;47.1) were employed, and 29.3% (95% CI, 9.0-55.3) lived independently. In adults without intellectual disability, proportions of individuals who were ambulant (72.6% [95% CI, 58.8-84.5]) and lived independently (90.0% [95% CI, 83.8-94.9]) were higher (P=.014 and P |
| doi_str_mv | 10.1016/j.apmr.2020.01.009 |
| format | Article |
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Embase, MEDLINE, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane, and Google Scholar were searched for 3 themes (“cerebral palsy,” “adult,” and “outcome assessment”) in literature published between January 2000 and December 2018.
Full-article peer-reviewed English journal articles on descriptive, observational, or experimental studies describing the most studied outcomes in adults with CP (n≥25, age≥18y) were included. Studies were included in the analyses if frequently studied outcomes were described in at least 3 studies using similar methods of assessment.
Data were extracted independently by 2 authors from 65 articles (total N=28,429) using a standardized score sheet.
Meta-analyses revealed that overall, on average 65.1% (95% confidence interval [CI], 55.1-74.5) of adults with CP experienced pain, 57.9% (95% CI, 51.1-64.6) were ambulant, 65.5% (95% CI, 61.2-69.7) had little or no limitation in manual ability, 18.2% (95% CI, 10.6-27.2) had tertiary education, 39.2% (95% CI, 31.5;47.1) were employed, and 29.3% (95% CI, 9.0-55.3) lived independently. In adults without intellectual disability, proportions of individuals who were ambulant (72.6% [95% CI, 58.8-84.5]) and lived independently (90.0% [95% CI, 83.8-94.9]) were higher (P=.014 and P<.01, respectively). The Fatigue Severity Scale score was 4.1 (95% CI, 3.8-4.4). Epilepsy (28.8% [95% CI, 20.1-38.4]) and asthma (28.3% [95% CI, 18.7-38.9]) were especially prevalent comorbidities.
The present systematic review and meta-analysis on the epidemiology of adults with CP provided state-of-the-art knowledge on the most frequently studied outcomes. On average, adults with CP are fatigued, and a majority experience pain, are ambulant, and have little or no difficulty with manual ability. On average, 40% are employed and 30% live independently. More uniformity in assessment and reports is advised to improve knowledge on epidemiology and gain insight in more outcomes.
•On average, adults with cerebral palsy (CP) are fatigued, and a majority experience pain.•A minority of adults with CP are employed and live independently.•Those without intellectual disability are often ambulant and live independently.•Epilepsy and asthma are common comorbidities in adults with CP.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1016/j.apmr.2020.01.009</identifier><identifier>PMID: 32059945</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Cerebral palsy ; Epidemiology ; Health ; Meta-analysis ; Rehabilitation ; Systematic review</subject><ispartof>Archives of physical medicine and rehabilitation, 2020-06, Vol.101 (6), p.1041-1052</ispartof><rights>2020 American Congress of Rehabilitation Medicine</rights><rights>Copyright © 2020 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-56a125057f557fc3d70ece23cea4c99c2e051d23e2e454548e686280a87fff213</citedby><cites>FETCH-LOGICAL-c400t-56a125057f557fc3d70ece23cea4c99c2e051d23e2e454548e686280a87fff213</cites><orcidid>0000-0002-1690-5926 ; 0000-0003-3754-9112</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apmr.2020.01.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32059945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Gorp, Marloes</creatorcontrib><creatorcontrib>Hilberink, Sander R.</creatorcontrib><creatorcontrib>Noten, Suzie</creatorcontrib><creatorcontrib>Benner, Joyce L.</creatorcontrib><creatorcontrib>Stam, Henk J.</creatorcontrib><creatorcontrib>van der Slot, Wilma M.A.</creatorcontrib><creatorcontrib>Roebroeck, Marij E.</creatorcontrib><title>Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>To describe the epidemiology of health status, impairments, activities and participation in adults with cerebral palsy (CP).
Embase, MEDLINE, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane, and Google Scholar were searched for 3 themes (“cerebral palsy,” “adult,” and “outcome assessment”) in literature published between January 2000 and December 2018.
Full-article peer-reviewed English journal articles on descriptive, observational, or experimental studies describing the most studied outcomes in adults with CP (n≥25, age≥18y) were included. Studies were included in the analyses if frequently studied outcomes were described in at least 3 studies using similar methods of assessment.
Data were extracted independently by 2 authors from 65 articles (total N=28,429) using a standardized score sheet.
Meta-analyses revealed that overall, on average 65.1% (95% confidence interval [CI], 55.1-74.5) of adults with CP experienced pain, 57.9% (95% CI, 51.1-64.6) were ambulant, 65.5% (95% CI, 61.2-69.7) had little or no limitation in manual ability, 18.2% (95% CI, 10.6-27.2) had tertiary education, 39.2% (95% CI, 31.5;47.1) were employed, and 29.3% (95% CI, 9.0-55.3) lived independently. In adults without intellectual disability, proportions of individuals who were ambulant (72.6% [95% CI, 58.8-84.5]) and lived independently (90.0% [95% CI, 83.8-94.9]) were higher (P=.014 and P<.01, respectively). The Fatigue Severity Scale score was 4.1 (95% CI, 3.8-4.4). Epilepsy (28.8% [95% CI, 20.1-38.4]) and asthma (28.3% [95% CI, 18.7-38.9]) were especially prevalent comorbidities.
The present systematic review and meta-analysis on the epidemiology of adults with CP provided state-of-the-art knowledge on the most frequently studied outcomes. On average, adults with CP are fatigued, and a majority experience pain, are ambulant, and have little or no difficulty with manual ability. On average, 40% are employed and 30% live independently. More uniformity in assessment and reports is advised to improve knowledge on epidemiology and gain insight in more outcomes.
•On average, adults with cerebral palsy (CP) are fatigued, and a majority experience pain.•A minority of adults with CP are employed and live independently.•Those without intellectual disability are often ambulant and live independently.•Epilepsy and asthma are common comorbidities in adults with CP.</description><subject>Adult</subject><subject>Cerebral palsy</subject><subject>Epidemiology</subject><subject>Health</subject><subject>Meta-analysis</subject><subject>Rehabilitation</subject><subject>Systematic review</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kFFrFDEQx0NR2rP6BXyQPPqy6yS57G3El-O4qtBSsS34FtJk1ubY3ZxJ1rL99Oa46qMMwzDwn__M_Ah5y6BmwJoPu9rsh1hz4FADqwHUCVkwKXjVcvbjBVkAgKiUUuKMvEppV9pGCnZKzgQHqdRSLsjTdu8dDj704edMQ0c3GPE-mp5-M32aqR_p2k19fgjBfaRrejOnjIPJ3tLv-NvjIzWjo1eYTWVG08_Jp4NLfkB6FVKmFxF_TTjmfqY3eXIeHb2esg0DptfkZVd24Jvnek7uLra3my_V5fXnr5v1ZWWXALmSjWFcglx1sqQVbgVokQuLZmmVshxBMscFclzKEi02bcNbMO2q6zrOxDl5f_Tdx1BuSVkPPlnsezNimJLmQkpVwIAoUn6U2hhSitjpffSDibNmoA_M9U4fmOsDcw1MF-Zl6N2z_3Q_oPs38hdyEXw6CrB8WZhFnazH0aLzEW3WLvj_-f8BJrCTZw</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>van Gorp, Marloes</creator><creator>Hilberink, Sander R.</creator><creator>Noten, Suzie</creator><creator>Benner, Joyce L.</creator><creator>Stam, Henk J.</creator><creator>van der Slot, Wilma M.A.</creator><creator>Roebroeck, Marij E.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1690-5926</orcidid><orcidid>https://orcid.org/0000-0003-3754-9112</orcidid></search><sort><creationdate>20200601</creationdate><title>Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes</title><author>van Gorp, Marloes ; Hilberink, Sander R. ; Noten, Suzie ; Benner, Joyce L. ; Stam, Henk J. ; van der Slot, Wilma M.A. ; Roebroeck, Marij E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-56a125057f557fc3d70ece23cea4c99c2e051d23e2e454548e686280a87fff213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cerebral palsy</topic><topic>Epidemiology</topic><topic>Health</topic><topic>Meta-analysis</topic><topic>Rehabilitation</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Gorp, Marloes</creatorcontrib><creatorcontrib>Hilberink, Sander R.</creatorcontrib><creatorcontrib>Noten, Suzie</creatorcontrib><creatorcontrib>Benner, Joyce L.</creatorcontrib><creatorcontrib>Stam, Henk J.</creatorcontrib><creatorcontrib>van der Slot, Wilma M.A.</creatorcontrib><creatorcontrib>Roebroeck, Marij E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Gorp, Marloes</au><au>Hilberink, Sander R.</au><au>Noten, Suzie</au><au>Benner, Joyce L.</au><au>Stam, Henk J.</au><au>van der Slot, Wilma M.A.</au><au>Roebroeck, Marij E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>101</volume><issue>6</issue><spage>1041</spage><epage>1052</epage><pages>1041-1052</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><abstract>To describe the epidemiology of health status, impairments, activities and participation in adults with cerebral palsy (CP).
Embase, MEDLINE, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane, and Google Scholar were searched for 3 themes (“cerebral palsy,” “adult,” and “outcome assessment”) in literature published between January 2000 and December 2018.
Full-article peer-reviewed English journal articles on descriptive, observational, or experimental studies describing the most studied outcomes in adults with CP (n≥25, age≥18y) were included. Studies were included in the analyses if frequently studied outcomes were described in at least 3 studies using similar methods of assessment.
Data were extracted independently by 2 authors from 65 articles (total N=28,429) using a standardized score sheet.
Meta-analyses revealed that overall, on average 65.1% (95% confidence interval [CI], 55.1-74.5) of adults with CP experienced pain, 57.9% (95% CI, 51.1-64.6) were ambulant, 65.5% (95% CI, 61.2-69.7) had little or no limitation in manual ability, 18.2% (95% CI, 10.6-27.2) had tertiary education, 39.2% (95% CI, 31.5;47.1) were employed, and 29.3% (95% CI, 9.0-55.3) lived independently. In adults without intellectual disability, proportions of individuals who were ambulant (72.6% [95% CI, 58.8-84.5]) and lived independently (90.0% [95% CI, 83.8-94.9]) were higher (P=.014 and P<.01, respectively). The Fatigue Severity Scale score was 4.1 (95% CI, 3.8-4.4). Epilepsy (28.8% [95% CI, 20.1-38.4]) and asthma (28.3% [95% CI, 18.7-38.9]) were especially prevalent comorbidities.
The present systematic review and meta-analysis on the epidemiology of adults with CP provided state-of-the-art knowledge on the most frequently studied outcomes. On average, adults with CP are fatigued, and a majority experience pain, are ambulant, and have little or no difficulty with manual ability. On average, 40% are employed and 30% live independently. More uniformity in assessment and reports is advised to improve knowledge on epidemiology and gain insight in more outcomes.
•On average, adults with cerebral palsy (CP) are fatigued, and a majority experience pain.•A minority of adults with CP are employed and live independently.•Those without intellectual disability are often ambulant and live independently.•Epilepsy and asthma are common comorbidities in adults with CP.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32059945</pmid><doi>10.1016/j.apmr.2020.01.009</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1690-5926</orcidid><orcidid>https://orcid.org/0000-0003-3754-9112</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Cerebral palsy Epidemiology Health Meta-analysis Rehabilitation Systematic review |
| title | Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes |
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