The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis
•Angpt-2/1 ratio was a good predictor for 28-day mortality in patients with sepsis.•Angpt-2/1 ratio > 3.2 can be used as a prognostic predictor for the 28-day mortality.•Plasma Angpt-2 was well correlated with variable cytokines such as IL-6 and TNF-α. We aimed to investigate the role of angiopoi...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2020-05, Vol.129, p.155029-155029, Article 155029 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Seol, Chang Hwan Yong, Seung Hyun Shin, Ju Hye Lee, Su Hwan Leem, Ah Young Park, Moo Suk Kim, Young Sam Chung, Kyung Soo |
| description | •Angpt-2/1 ratio was a good predictor for 28-day mortality in patients with sepsis.•Angpt-2/1 ratio > 3.2 can be used as a prognostic predictor for the 28-day mortality.•Plasma Angpt-2 was well correlated with variable cytokines such as IL-6 and TNF-α.
We aimed to investigate the role of angiopoietin (Angpt) as a predictive biomarker for sepsis by evaluating associations between plasma Angpt and various inflammatory cytokines and mortality in critically ill patients with sepsis.
This study was a retrospective cohort study of the prospectively collected samples and clinical data of 145 patients with sepsis who were admitted to the medical intensive care unit (ICU) of a 2000-bed university tertiary referral hospital in South Korea. We collected plasma within 24 h of medical ICU admission, and several biomarkers (Angpt-1 and -2, Tie2, vascular endothelial growth factor, interleukin (IL)-1β, IL-10, IL-18, IL-6, interferon gamma-induced protein-10, and tumor necrosis factor-α) were measured using a Human Magnetic Luminex Screening Assay kit.
Plasma Angpt-2 was correlated with IL-6 (rs = 0.555) and tumor necrosis factor-α (rs = 0.559). Plasma Angpt-2 (rs = 0.530) and Angpt-2/1 (rs = 0.562) were correlated with the Sequential Organ Failure Assessment (SOFA) score. The area under the curve (AUC) for the 28-day mortality prediction for the plasma Angpt-2/1 ratio was 0.736; AUCs for the Acute Physiology and Chronic Health Evaluation II (APACHE II) and SOFA scores were 0.659 and 0.745, respectively. Using multivariate Cox proportional hazard regression analysis for 28-day mortality, we found that acute respiratory distress syndrome (hazard ratio (HR) = 2.235, 95% CI = 1.163–4.296,p = 0.016), APACHE II score (HR = 1.127, 95% CI = 1.037–1.224,p = 0.005), and Angpt-2/1 > 3.2 (HR = 2.522, 95% CI = 1.205–5.278,p = 0.014) were risk factors for 28-day mortality.
Plasma Angpt-2 was related to cytokines, but Angpt-2/1 ratio was a good predictor of 28-day mortality in patients with sepsis. |
| doi_str_mv | 10.1016/j.cyto.2020.155029 |
| format | Article |
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We aimed to investigate the role of angiopoietin (Angpt) as a predictive biomarker for sepsis by evaluating associations between plasma Angpt and various inflammatory cytokines and mortality in critically ill patients with sepsis.
This study was a retrospective cohort study of the prospectively collected samples and clinical data of 145 patients with sepsis who were admitted to the medical intensive care unit (ICU) of a 2000-bed university tertiary referral hospital in South Korea. We collected plasma within 24 h of medical ICU admission, and several biomarkers (Angpt-1 and -2, Tie2, vascular endothelial growth factor, interleukin (IL)-1β, IL-10, IL-18, IL-6, interferon gamma-induced protein-10, and tumor necrosis factor-α) were measured using a Human Magnetic Luminex Screening Assay kit.
Plasma Angpt-2 was correlated with IL-6 (rs = 0.555) and tumor necrosis factor-α (rs = 0.559). Plasma Angpt-2 (rs = 0.530) and Angpt-2/1 (rs = 0.562) were correlated with the Sequential Organ Failure Assessment (SOFA) score. The area under the curve (AUC) for the 28-day mortality prediction for the plasma Angpt-2/1 ratio was 0.736; AUCs for the Acute Physiology and Chronic Health Evaluation II (APACHE II) and SOFA scores were 0.659 and 0.745, respectively. Using multivariate Cox proportional hazard regression analysis for 28-day mortality, we found that acute respiratory distress syndrome (hazard ratio (HR) = 2.235, 95% CI = 1.163–4.296,p = 0.016), APACHE II score (HR = 1.127, 95% CI = 1.037–1.224,p = 0.005), and Angpt-2/1 > 3.2 (HR = 2.522, 95% CI = 1.205–5.278,p = 0.014) were risk factors for 28-day mortality.
Plasma Angpt-2 was related to cytokines, but Angpt-2/1 ratio was a good predictor of 28-day mortality in patients with sepsis.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2020.155029</identifier><identifier>PMID: 32059166</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Angiopoietin ; Mortality ; Prediction ; Sepsis</subject><ispartof>Cytokine (Philadelphia, Pa.), 2020-05, Vol.129, p.155029-155029, Article 155029</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-56f51ee53c2f3c4bcb263f6eacc319e3c9e7f1a6e31a31eee6a3feacca6639a13</citedby><cites>FETCH-LOGICAL-c356t-56f51ee53c2f3c4bcb263f6eacc319e3c9e7f1a6e31a31eee6a3feacca6639a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2020.155029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32059166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seol, Chang Hwan</creatorcontrib><creatorcontrib>Yong, Seung Hyun</creatorcontrib><creatorcontrib>Shin, Ju Hye</creatorcontrib><creatorcontrib>Lee, Su Hwan</creatorcontrib><creatorcontrib>Leem, Ah Young</creatorcontrib><creatorcontrib>Park, Moo Suk</creatorcontrib><creatorcontrib>Kim, Young Sam</creatorcontrib><creatorcontrib>Chung, Kyung Soo</creatorcontrib><title>The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>•Angpt-2/1 ratio was a good predictor for 28-day mortality in patients with sepsis.•Angpt-2/1 ratio > 3.2 can be used as a prognostic predictor for the 28-day mortality.•Plasma Angpt-2 was well correlated with variable cytokines such as IL-6 and TNF-α.
We aimed to investigate the role of angiopoietin (Angpt) as a predictive biomarker for sepsis by evaluating associations between plasma Angpt and various inflammatory cytokines and mortality in critically ill patients with sepsis.
This study was a retrospective cohort study of the prospectively collected samples and clinical data of 145 patients with sepsis who were admitted to the medical intensive care unit (ICU) of a 2000-bed university tertiary referral hospital in South Korea. We collected plasma within 24 h of medical ICU admission, and several biomarkers (Angpt-1 and -2, Tie2, vascular endothelial growth factor, interleukin (IL)-1β, IL-10, IL-18, IL-6, interferon gamma-induced protein-10, and tumor necrosis factor-α) were measured using a Human Magnetic Luminex Screening Assay kit.
Plasma Angpt-2 was correlated with IL-6 (rs = 0.555) and tumor necrosis factor-α (rs = 0.559). Plasma Angpt-2 (rs = 0.530) and Angpt-2/1 (rs = 0.562) were correlated with the Sequential Organ Failure Assessment (SOFA) score. The area under the curve (AUC) for the 28-day mortality prediction for the plasma Angpt-2/1 ratio was 0.736; AUCs for the Acute Physiology and Chronic Health Evaluation II (APACHE II) and SOFA scores were 0.659 and 0.745, respectively. Using multivariate Cox proportional hazard regression analysis for 28-day mortality, we found that acute respiratory distress syndrome (hazard ratio (HR) = 2.235, 95% CI = 1.163–4.296,p = 0.016), APACHE II score (HR = 1.127, 95% CI = 1.037–1.224,p = 0.005), and Angpt-2/1 > 3.2 (HR = 2.522, 95% CI = 1.205–5.278,p = 0.014) were risk factors for 28-day mortality.
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We aimed to investigate the role of angiopoietin (Angpt) as a predictive biomarker for sepsis by evaluating associations between plasma Angpt and various inflammatory cytokines and mortality in critically ill patients with sepsis.
This study was a retrospective cohort study of the prospectively collected samples and clinical data of 145 patients with sepsis who were admitted to the medical intensive care unit (ICU) of a 2000-bed university tertiary referral hospital in South Korea. We collected plasma within 24 h of medical ICU admission, and several biomarkers (Angpt-1 and -2, Tie2, vascular endothelial growth factor, interleukin (IL)-1β, IL-10, IL-18, IL-6, interferon gamma-induced protein-10, and tumor necrosis factor-α) were measured using a Human Magnetic Luminex Screening Assay kit.
Plasma Angpt-2 was correlated with IL-6 (rs = 0.555) and tumor necrosis factor-α (rs = 0.559). Plasma Angpt-2 (rs = 0.530) and Angpt-2/1 (rs = 0.562) were correlated with the Sequential Organ Failure Assessment (SOFA) score. The area under the curve (AUC) for the 28-day mortality prediction for the plasma Angpt-2/1 ratio was 0.736; AUCs for the Acute Physiology and Chronic Health Evaluation II (APACHE II) and SOFA scores were 0.659 and 0.745, respectively. Using multivariate Cox proportional hazard regression analysis for 28-day mortality, we found that acute respiratory distress syndrome (hazard ratio (HR) = 2.235, 95% CI = 1.163–4.296,p = 0.016), APACHE II score (HR = 1.127, 95% CI = 1.037–1.224,p = 0.005), and Angpt-2/1 > 3.2 (HR = 2.522, 95% CI = 1.205–5.278,p = 0.014) were risk factors for 28-day mortality.
Plasma Angpt-2 was related to cytokines, but Angpt-2/1 ratio was a good predictor of 28-day mortality in patients with sepsis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32059166</pmid><doi>10.1016/j.cyto.2020.155029</doi><tpages>1</tpages></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Angiopoietin Mortality Prediction Sepsis |
| title | The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis |
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