Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014
Hospitalizations in pulmonary arterial hypertension (PAH) are common and are often for cardiac conditions. Using the National (Nationwide) Inpatient Sample (NIS), we examined characteristics and mortality of primary cardiac hospitalizations in PAH from 2001 to 2014. Adult hospitalizations with any d...
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| Veröffentlicht in: | Respiratory medicine 2020-01, Vol.161, p.105850-105850, Article 105850 |
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| description | Hospitalizations in pulmonary arterial hypertension (PAH) are common and are often for cardiac conditions. Using the National (Nationwide) Inpatient Sample (NIS), we examined characteristics and mortality of primary cardiac hospitalizations in PAH from 2001 to 2014.
Adult hospitalizations with any diagnosis code for PAH were identified. Primary cardiac disease was defined as a primary discharge diagnosis of congestive heart failure (CHF), pulmonary heart disease, coronary atherosclerosis, acute myocardial infarction, dysrhythmia, conduction disorder, cardiomyopathy or carditis, heart valve disorder, or cardiac arrest. Temporal trends, characteristics, and in-hospital mortality were analyzed.
From 2001 to 2014, there were 207,095 hospitalizations in PAH, of which 100,509 (48.5%) carried a primary cardiac diagnosis. Most primary cardiac hospitalizations in PAH were for CHF, and pneumonia was the most common primary non-cardiac diagnosis. Over the study period, primary cardiac hospitalizations in PAH fell from 52.9% to 41.4% (p |
| doi_str_mv | 10.1016/j.rmed.2019.105850 |
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Adult hospitalizations with any diagnosis code for PAH were identified. Primary cardiac disease was defined as a primary discharge diagnosis of congestive heart failure (CHF), pulmonary heart disease, coronary atherosclerosis, acute myocardial infarction, dysrhythmia, conduction disorder, cardiomyopathy or carditis, heart valve disorder, or cardiac arrest. Temporal trends, characteristics, and in-hospital mortality were analyzed.
From 2001 to 2014, there were 207,095 hospitalizations in PAH, of which 100,509 (48.5%) carried a primary cardiac diagnosis. Most primary cardiac hospitalizations in PAH were for CHF, and pneumonia was the most common primary non-cardiac diagnosis. Over the study period, primary cardiac hospitalizations in PAH fell from 52.9% to 41.4% (p < 0.001). CHF was the most frequent primary cardiac diagnosis associated with death, with sepsis representing the most common primary non-cardiac disease (1,226; 25.0%). Overall, the mortality in primary cardiac hospitalizations in PAH was 5.3% (vs. in primary non-cardiac, 6.9%, p < 0.001). On multivariable analysis, a primary cardiac discharge diagnosis remained associated with a decreased risk of death (odds ratio 0.85, p = 0.010).
Primary cardiac hospitalizations in PAH are common and are associated with decreased mortality compared to admissions for primary non-cardiac diagnoses.
•In a large U.S. database, 48.5% of PAH hospitalizations were for cardiac diagnoses.•From 2001 to 2014, there was a decrease in admissions in PAH for cardiac diagnoses.•The mortality in cardiac hospitalizations in PAH was 5.3% (vs. 6.8% in non-cardiac).•PAH admissions for cardiac diagnoses were associated with decreased risk of death.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2019.105850</identifier><identifier>PMID: 32056724</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age ; Arteriosclerosis ; Atherosclerosis ; Cardiac arrhythmia ; Cardiac hospitalizations ; Cardiomyopathy ; Cardiovascular disease ; Cardiovascular diseases ; Carditis ; Clinical outcomes ; Codes ; Comorbidity ; Conduction ; Congestive heart failure ; Coronary artery disease ; Diagnosis ; Discharge ; Heart failure ; Heart valves ; Hypertension ; Identification methods ; Kidney diseases ; Lung diseases ; Mortality ; Myocardial infarction ; Outcomes ; Population ; Pulmonary arterial hypertension ; Pulmonary hypertension ; Rheumatic heart disease ; Sepsis ; Statistical analysis ; Trends</subject><ispartof>Respiratory medicine, 2020-01, Vol.161, p.105850-105850, Article 105850</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>2019. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-c2d5b6711b75680d2107e149fd58e1c905d6544f6334e7db49b7c25a4d2278de3</citedby><cites>FETCH-LOGICAL-c494t-c2d5b6711b75680d2107e149fd58e1c905d6544f6334e7db49b7c25a4d2278de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611119303646$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32056724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harder, Eileen M.</creatorcontrib><creatorcontrib>Small, Aeron M.</creatorcontrib><creatorcontrib>Fares, Wassim H.</creatorcontrib><title>Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Hospitalizations in pulmonary arterial hypertension (PAH) are common and are often for cardiac conditions. Using the National (Nationwide) Inpatient Sample (NIS), we examined characteristics and mortality of primary cardiac hospitalizations in PAH from 2001 to 2014.
Adult hospitalizations with any diagnosis code for PAH were identified. Primary cardiac disease was defined as a primary discharge diagnosis of congestive heart failure (CHF), pulmonary heart disease, coronary atherosclerosis, acute myocardial infarction, dysrhythmia, conduction disorder, cardiomyopathy or carditis, heart valve disorder, or cardiac arrest. Temporal trends, characteristics, and in-hospital mortality were analyzed.
From 2001 to 2014, there were 207,095 hospitalizations in PAH, of which 100,509 (48.5%) carried a primary cardiac diagnosis. Most primary cardiac hospitalizations in PAH were for CHF, and pneumonia was the most common primary non-cardiac diagnosis. Over the study period, primary cardiac hospitalizations in PAH fell from 52.9% to 41.4% (p < 0.001). CHF was the most frequent primary cardiac diagnosis associated with death, with sepsis representing the most common primary non-cardiac disease (1,226; 25.0%). Overall, the mortality in primary cardiac hospitalizations in PAH was 5.3% (vs. in primary non-cardiac, 6.9%, p < 0.001). On multivariable analysis, a primary cardiac discharge diagnosis remained associated with a decreased risk of death (odds ratio 0.85, p = 0.010).
Primary cardiac hospitalizations in PAH are common and are associated with decreased mortality compared to admissions for primary non-cardiac diagnoses.
•In a large U.S. database, 48.5% of PAH hospitalizations were for cardiac diagnoses.•From 2001 to 2014, there was a decrease in admissions in PAH for cardiac diagnoses.•The mortality in cardiac hospitalizations in PAH was 5.3% (vs. 6.8% in non-cardiac).•PAH admissions for cardiac diagnoses were associated with decreased risk of death.</description><subject>Age</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac hospitalizations</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Carditis</subject><subject>Clinical outcomes</subject><subject>Codes</subject><subject>Comorbidity</subject><subject>Conduction</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Diagnosis</subject><subject>Discharge</subject><subject>Heart failure</subject><subject>Heart valves</subject><subject>Hypertension</subject><subject>Identification methods</subject><subject>Kidney diseases</subject><subject>Lung diseases</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Outcomes</subject><subject>Population</subject><subject>Pulmonary arterial hypertension</subject><subject>Pulmonary hypertension</subject><subject>Rheumatic heart disease</subject><subject>Sepsis</subject><subject>Statistical analysis</subject><subject>Trends</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU2L1zAQxoMo7t_VL-BBAl689G_e04qXZfENFvSwnkOaTNmUNqlJK6yf3pTuXjx4mmHmNw_D8yD0mpIzJVS9H895Bn9mhHZ1IFtJnqATlZw1nCjxFJ1IJ0WjKKUX6EUpIyGkE4I8RxecEak0Eyc0_shhtvkeO5t9sA7fpbKE1U7hj11DigWHiJdtmlPcKZtXyMFO-O5-gdrHUpkP-DZD9AXb6HHaVpdmKHjIacaMEIrXVCsVL9GzwU4FXj3US_Tz86fb66_Nzfcv366vbhonOrE2jnnZK01pr6VqiWeUaKCiG7xsgbqOSK-kEIPiXID2veh67Zi0wjOmWw_8Er07dJecfm1QVjOH4mCabIS0FcO4lJ1QLdcVffsPOqYtx_rdTjEiNOWyUuygXE6lZBjMcphmKDF7EmY0exJmT8IcSdSjNw_SW7_vHk8era_AxwOA6sXvANkUFyA68CGDW41P4X_6fwFOT5hs</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Harder, Eileen M.</creator><creator>Small, Aeron M.</creator><creator>Fares, Wassim H.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014</title><author>Harder, Eileen M. ; Small, Aeron M. ; Fares, Wassim H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-c2d5b6711b75680d2107e149fd58e1c905d6544f6334e7db49b7c25a4d2278de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac hospitalizations</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Carditis</topic><topic>Clinical outcomes</topic><topic>Codes</topic><topic>Comorbidity</topic><topic>Conduction</topic><topic>Congestive heart failure</topic><topic>Coronary artery disease</topic><topic>Diagnosis</topic><topic>Discharge</topic><topic>Heart failure</topic><topic>Heart valves</topic><topic>Hypertension</topic><topic>Identification methods</topic><topic>Kidney diseases</topic><topic>Lung diseases</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Outcomes</topic><topic>Population</topic><topic>Pulmonary arterial hypertension</topic><topic>Pulmonary hypertension</topic><topic>Rheumatic heart disease</topic><topic>Sepsis</topic><topic>Statistical analysis</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harder, Eileen M.</creatorcontrib><creatorcontrib>Small, Aeron M.</creatorcontrib><creatorcontrib>Fares, Wassim H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harder, Eileen M.</au><au>Small, Aeron M.</au><au>Fares, Wassim H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2020-01</date><risdate>2020</risdate><volume>161</volume><spage>105850</spage><epage>105850</epage><pages>105850-105850</pages><artnum>105850</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Hospitalizations in pulmonary arterial hypertension (PAH) are common and are often for cardiac conditions. Using the National (Nationwide) Inpatient Sample (NIS), we examined characteristics and mortality of primary cardiac hospitalizations in PAH from 2001 to 2014.
Adult hospitalizations with any diagnosis code for PAH were identified. Primary cardiac disease was defined as a primary discharge diagnosis of congestive heart failure (CHF), pulmonary heart disease, coronary atherosclerosis, acute myocardial infarction, dysrhythmia, conduction disorder, cardiomyopathy or carditis, heart valve disorder, or cardiac arrest. Temporal trends, characteristics, and in-hospital mortality were analyzed.
From 2001 to 2014, there were 207,095 hospitalizations in PAH, of which 100,509 (48.5%) carried a primary cardiac diagnosis. Most primary cardiac hospitalizations in PAH were for CHF, and pneumonia was the most common primary non-cardiac diagnosis. Over the study period, primary cardiac hospitalizations in PAH fell from 52.9% to 41.4% (p < 0.001). CHF was the most frequent primary cardiac diagnosis associated with death, with sepsis representing the most common primary non-cardiac disease (1,226; 25.0%). Overall, the mortality in primary cardiac hospitalizations in PAH was 5.3% (vs. in primary non-cardiac, 6.9%, p < 0.001). On multivariable analysis, a primary cardiac discharge diagnosis remained associated with a decreased risk of death (odds ratio 0.85, p = 0.010).
Primary cardiac hospitalizations in PAH are common and are associated with decreased mortality compared to admissions for primary non-cardiac diagnoses.
•In a large U.S. database, 48.5% of PAH hospitalizations were for cardiac diagnoses.•From 2001 to 2014, there was a decrease in admissions in PAH for cardiac diagnoses.•The mortality in cardiac hospitalizations in PAH was 5.3% (vs. 6.8% in non-cardiac).•PAH admissions for cardiac diagnoses were associated with decreased risk of death.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32056724</pmid><doi>10.1016/j.rmed.2019.105850</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Arteriosclerosis Atherosclerosis Cardiac arrhythmia Cardiac hospitalizations Cardiomyopathy Cardiovascular disease Cardiovascular diseases Carditis Clinical outcomes Codes Comorbidity Conduction Congestive heart failure Coronary artery disease Diagnosis Discharge Heart failure Heart valves Hypertension Identification methods Kidney diseases Lung diseases Mortality Myocardial infarction Outcomes Population Pulmonary arterial hypertension Pulmonary hypertension Rheumatic heart disease Sepsis Statistical analysis Trends |
| title | Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014 |
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