A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium
Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16a...
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| Veröffentlicht in: | Applied radiation and isotopes 2020-02, Vol.156, p.108985-108985, Article 108985 |
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| container_title | Applied radiation and isotopes |
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| creator | Jensen, Andreas I. Zhuravlev, Fedor Severin, Gregory Magnus, Charlotte Busk Fonslet, Jesper Köster, Ulli Jensen, Mikael |
| description | Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
•[103Pd]PdCl2 was obtained by dissolving neutron irradiated 102Pd-enriched targets.•[103Pd]Pd was chelated by a 16aneS4-octyl derivative and trapped on a C18 support.•Elution of this generator provided 103mRh in excellent radiochemical purity.•The demonstrated generator will allow investigating 103mRh for Auger radiotherapy. |
| doi_str_mv | 10.1016/j.apradiso.2019.108985 |
| format | Article |
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•[103Pd]PdCl2 was obtained by dissolving neutron irradiated 102Pd-enriched targets.•[103Pd]Pd was chelated by a 16aneS4-octyl derivative and trapped on a C18 support.•Elution of this generator provided 103mRh in excellent radiochemical purity.•The demonstrated generator will allow investigating 103mRh for Auger radiotherapy.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2019.108985</identifier><identifier>PMID: 32056685</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>16aneS4 ; Auger radiotherapy ; Palladium-103 ; Radionuclide generator ; Rhodium-103m</subject><ispartof>Applied radiation and isotopes, 2020-02, Vol.156, p.108985-108985, Article 108985</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-d4951d01d0ab85d28e228ab0348f2038a42053485806afc1564c0860abf58d133</citedby><cites>FETCH-LOGICAL-c416t-d4951d01d0ab85d28e228ab0348f2038a42053485806afc1564c0860abf58d133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0969804319306566$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32056685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Andreas I.</creatorcontrib><creatorcontrib>Zhuravlev, Fedor</creatorcontrib><creatorcontrib>Severin, Gregory</creatorcontrib><creatorcontrib>Magnus, Charlotte Busk</creatorcontrib><creatorcontrib>Fonslet, Jesper</creatorcontrib><creatorcontrib>Köster, Ulli</creatorcontrib><creatorcontrib>Jensen, Mikael</creatorcontrib><title>A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium</title><title>Applied radiation and isotopes</title><addtitle>Appl Radiat Isot</addtitle><description>Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
•[103Pd]PdCl2 was obtained by dissolving neutron irradiated 102Pd-enriched targets.•[103Pd]Pd was chelated by a 16aneS4-octyl derivative and trapped on a C18 support.•Elution of this generator provided 103mRh in excellent radiochemical purity.•The demonstrated generator will allow investigating 103mRh for Auger radiotherapy.</description><subject>16aneS4</subject><subject>Auger radiotherapy</subject><subject>Palladium-103</subject><subject>Radionuclide generator</subject><subject>Rhodium-103m</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkMtqGzEUQEVpaJzHLxgtuxnn6llpVxOathBIFskmpQh5dMeRmbGm0kwgf18ZJ90WBJKuzn3oELJksGLA9NVu5cfsQyxpxYHZGjTWqA9kwcwX3lgD8JEswGrbGJDilJyVsgMAaSz_RE4FB6W1UQvytKYl9THQMo9jyhPd4h6zn1KmqaPTM9L1vMVMscd2ymlPcYjTVAP5OYU4Dw0DMdAup4H-qsf78Hv0fe8PTxfkpPN9wcu3_Zw83nx7uP7R3N59_3m9vm1ayfTUBGkVC1CX3xgVuEHOjd-AkKbjIIyXddh6UQa071qmtGzB6Ep3ygQmxDn5fKw75vRnxjK5IZYW6xR7THNxXChlpbDSVlQf0TanUjJ2bsxx8PnVMXAHr27n3r26g1d39FoTl2895s2A4V_au8gKfD0CWH_6EjG70kbctxhiruZcSPF_Pf4CMbeLUw</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Jensen, Andreas I.</creator><creator>Zhuravlev, Fedor</creator><creator>Severin, Gregory</creator><creator>Magnus, Charlotte Busk</creator><creator>Fonslet, Jesper</creator><creator>Köster, Ulli</creator><creator>Jensen, Mikael</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium</title><author>Jensen, Andreas I. ; Zhuravlev, Fedor ; Severin, Gregory ; Magnus, Charlotte Busk ; Fonslet, Jesper ; Köster, Ulli ; Jensen, Mikael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-d4951d01d0ab85d28e228ab0348f2038a42053485806afc1564c0860abf58d133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>16aneS4</topic><topic>Auger radiotherapy</topic><topic>Palladium-103</topic><topic>Radionuclide generator</topic><topic>Rhodium-103m</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Andreas I.</creatorcontrib><creatorcontrib>Zhuravlev, Fedor</creatorcontrib><creatorcontrib>Severin, Gregory</creatorcontrib><creatorcontrib>Magnus, Charlotte Busk</creatorcontrib><creatorcontrib>Fonslet, Jesper</creatorcontrib><creatorcontrib>Köster, Ulli</creatorcontrib><creatorcontrib>Jensen, Mikael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Andreas I.</au><au>Zhuravlev, Fedor</au><au>Severin, Gregory</au><au>Magnus, Charlotte Busk</au><au>Fonslet, Jesper</au><au>Köster, Ulli</au><au>Jensen, Mikael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium</atitle><jtitle>Applied radiation and isotopes</jtitle><addtitle>Appl Radiat Isot</addtitle><date>2020-02</date><risdate>2020</risdate><volume>156</volume><spage>108985</spage><epage>108985</epage><pages>108985-108985</pages><artnum>108985</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
•[103Pd]PdCl2 was obtained by dissolving neutron irradiated 102Pd-enriched targets.•[103Pd]Pd was chelated by a 16aneS4-octyl derivative and trapped on a C18 support.•Elution of this generator provided 103mRh in excellent radiochemical purity.•The demonstrated generator will allow investigating 103mRh for Auger radiotherapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32056685</pmid><doi>10.1016/j.apradiso.2019.108985</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 16aneS4 Auger radiotherapy Palladium-103 Radionuclide generator Rhodium-103m |
| title | A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium |
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