In vitro and in vivo activities of multi-target phtalimido-thiazoles on Schistosomiasis mansoni

Schistosomicidal activity of six phthalimido-thiazoles derivatives with substitutions at the position three of the thiazole ring were analyzed in an experimental model. The substituents biphenyl (2i) and 2- naphthyl (2j) at a concentration of 80 µg/mL caused 100% mortality of the parasite in culture...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2020-04, Vol.146, p.105236-105236, Article 105236
Hauptverfasser:	Filho, Carlos André Laranjeira Miranda, Barbosa, Miria de Oliveira, Oliveira, Arsênio Rodrigues, Santiago, Edna Farias, de Souza, Veruska Cintia Alexandrino, Lucena, Jéssica Paula, Fernandes, Camila Juliet Barbosa, Santos, Ignes Regina dos, Leão, Renata Lins Carneiro, Santos, Fabio André Brayner dos, Alves, Luiz Carlos, Pereira, Valéria Rego Alves, de Araújo, Roni Evêncio, Leite, Ana Cristina Lima, de Oliveira, Sheilla Andrade
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Female In vitro In Vitro Techniques In vivo Male Mice Parasite Egg Count Phthalimide Phthalimides - chemistry Schistosma Schistosoma mansoni - drug effects Schistosoma mansoni - isolation & purification Schistosomiasis Schistosomiasis mansoni - drug therapy Spectroscopy, Fourier Transform Infrared Thiazole Thiazoles - chemistry Thiazoles - pharmacology
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