Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review
[Display omitted] During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased, especially on those demonstrating to be effective on cancer. Molecules coming from nature are currently used in chemotherapy like Taxol, Vincrist...
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| Veröffentlicht in: | Pharmacological research 2020-05, Vol.155, p.104689-104689, Article 104689 |
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| container_title | Pharmacological research |
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| creator | Faraone, Immacolata Sinisgalli, Chiara Ostuni, Angela Armentano, Maria Francesca Carmosino, Monica Milella, Luigi Russo, Daniela Labanca, Fabiana Khan, Haroon |
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During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased, especially on those demonstrating to be effective on cancer. Molecules coming from nature are currently used in chemotherapy like Taxol, Vincristine or Vinblastine, and several other natural substances have been showed to be active in reducing cancer cell progression and migration. Among them, astaxanthin, a xanthophyll red colored carotenoid, displayed different biological activities including, antinflammatory, antioxidant, proapoptotic, and anticancer effects. It can induce apoptosis through downregulation of antiapoptotic protein (Bcl-2, p-Bad, and survivin) expression and upregulation of proapoptotic ones (Bax/Bad and PARP). Thanks to these mechanisms, it can exert anticancer effects towards colorectal cancer, melanoma, or gastric carcinoma cell lines. Moreover, it possesses antiproliferative activity in many experimental models and enhances the effectiveness of conventional chemotherapic drugs on tumor cells underling its potential future use. This review provides an overview of the current knowledge on the anticancer potential of astaxanthin by modulating several molecular targets. While it has been clearly demonstrated its multitarget activity in the prevention and regression of malignant cells in in vitro or in preclinical investigations, further clinical studies are needed to assess its real potential as anticancer in humans. |
| doi_str_mv | 10.1016/j.phrs.2020.104689 |
| format | Article |
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During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased, especially on those demonstrating to be effective on cancer. Molecules coming from nature are currently used in chemotherapy like Taxol, Vincristine or Vinblastine, and several other natural substances have been showed to be active in reducing cancer cell progression and migration. Among them, astaxanthin, a xanthophyll red colored carotenoid, displayed different biological activities including, antinflammatory, antioxidant, proapoptotic, and anticancer effects. It can induce apoptosis through downregulation of antiapoptotic protein (Bcl-2, p-Bad, and survivin) expression and upregulation of proapoptotic ones (Bax/Bad and PARP). Thanks to these mechanisms, it can exert anticancer effects towards colorectal cancer, melanoma, or gastric carcinoma cell lines. Moreover, it possesses antiproliferative activity in many experimental models and enhances the effectiveness of conventional chemotherapic drugs on tumor cells underling its potential future use. This review provides an overview of the current knowledge on the anticancer potential of astaxanthin by modulating several molecular targets. While it has been clearly demonstrated its multitarget activity in the prevention and regression of malignant cells in in vitro or in preclinical investigations, further clinical studies are needed to assess its real potential as anticancer in humans.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2020.104689</identifier><identifier>PMID: 32057895</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Apoptosis - drug effects ; Cancer prevention ; Cell cycle ; Cell Cycle Checkpoints - drug effects ; Humans ; Malignancy ; Neoplasms - drug therapy ; Proapoptotic ; Staxanthin ; Survivina ; Xanthophylls - pharmacology ; Xanthophylls - therapeutic use</subject><ispartof>Pharmacological research, 2020-05, Vol.155, p.104689-104689, Article 104689</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-2eb388f4cb556a95fc456e23269a3628542aef0cc50d9a891194123f01a6aba63</citedby><cites>FETCH-LOGICAL-c400t-2eb388f4cb556a95fc456e23269a3628542aef0cc50d9a891194123f01a6aba63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043661819327367$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32057895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faraone, Immacolata</creatorcontrib><creatorcontrib>Sinisgalli, Chiara</creatorcontrib><creatorcontrib>Ostuni, Angela</creatorcontrib><creatorcontrib>Armentano, Maria Francesca</creatorcontrib><creatorcontrib>Carmosino, Monica</creatorcontrib><creatorcontrib>Milella, Luigi</creatorcontrib><creatorcontrib>Russo, Daniela</creatorcontrib><creatorcontrib>Labanca, Fabiana</creatorcontrib><creatorcontrib>Khan, Haroon</creatorcontrib><title>Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>[Display omitted]
During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased, especially on those demonstrating to be effective on cancer. Molecules coming from nature are currently used in chemotherapy like Taxol, Vincristine or Vinblastine, and several other natural substances have been showed to be active in reducing cancer cell progression and migration. Among them, astaxanthin, a xanthophyll red colored carotenoid, displayed different biological activities including, antinflammatory, antioxidant, proapoptotic, and anticancer effects. It can induce apoptosis through downregulation of antiapoptotic protein (Bcl-2, p-Bad, and survivin) expression and upregulation of proapoptotic ones (Bax/Bad and PARP). Thanks to these mechanisms, it can exert anticancer effects towards colorectal cancer, melanoma, or gastric carcinoma cell lines. Moreover, it possesses antiproliferative activity in many experimental models and enhances the effectiveness of conventional chemotherapic drugs on tumor cells underling its potential future use. This review provides an overview of the current knowledge on the anticancer potential of astaxanthin by modulating several molecular targets. While it has been clearly demonstrated its multitarget activity in the prevention and regression of malignant cells in in vitro or in preclinical investigations, further clinical studies are needed to assess its real potential as anticancer in humans.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Cancer prevention</subject><subject>Cell cycle</subject><subject>Cell Cycle Checkpoints - drug effects</subject><subject>Humans</subject><subject>Malignancy</subject><subject>Neoplasms - drug therapy</subject><subject>Proapoptotic</subject><subject>Staxanthin</subject><subject>Survivina</subject><subject>Xanthophylls - pharmacology</subject><subject>Xanthophylls - therapeutic use</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtuFDEQRS0EIg_4ARaRl9n04Efb2FE2owgIUiQ2sLZq3GXao35MbHdI_h63JsmSVVmuU1e6h5BPnG044_rzfnPoU94IJtaPVhv7hpxyZnXDudFv13crG625OSFnOe8ZY7bl7D05kYKpL8aqUxK2ucAjTKWPE60jepg8JoohoC-ZQkI6YhehYEdLn-blT0_HZSjxMNTNPKBfBkiV8T1MMY_5im5pfsoFR6hpNOFDxL8fyLsAQ8aPz_Oc_P729dfNbXP38_uPm-1d41vGSiNwJ40Jrd8ppcGq4FulUUihLUgtjGoFYGDeK9ZZMJbzWkjIwDho2IGW5-TymHtI8_2CubgxZo_DABPOS3ZCKmWlttJUVBxRn-acEwZ3SHGE9OQ4c6tft3erX7f6dUe_9ejiOX_ZVS2vJy9CK3B9BLC2rM2Tyz5iVdrFVIW6bo7_y_8HUEiNaA</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Faraone, Immacolata</creator><creator>Sinisgalli, Chiara</creator><creator>Ostuni, Angela</creator><creator>Armentano, Maria Francesca</creator><creator>Carmosino, Monica</creator><creator>Milella, Luigi</creator><creator>Russo, Daniela</creator><creator>Labanca, Fabiana</creator><creator>Khan, Haroon</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202005</creationdate><title>Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review</title><author>Faraone, Immacolata ; Sinisgalli, Chiara ; Ostuni, Angela ; Armentano, Maria Francesca ; Carmosino, Monica ; Milella, Luigi ; Russo, Daniela ; Labanca, Fabiana ; Khan, Haroon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-2eb388f4cb556a95fc456e23269a3628542aef0cc50d9a891194123f01a6aba63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Apoptosis - drug effects</topic><topic>Cancer prevention</topic><topic>Cell cycle</topic><topic>Cell Cycle Checkpoints - drug effects</topic><topic>Humans</topic><topic>Malignancy</topic><topic>Neoplasms - drug therapy</topic><topic>Proapoptotic</topic><topic>Staxanthin</topic><topic>Survivina</topic><topic>Xanthophylls - pharmacology</topic><topic>Xanthophylls - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faraone, Immacolata</creatorcontrib><creatorcontrib>Sinisgalli, Chiara</creatorcontrib><creatorcontrib>Ostuni, Angela</creatorcontrib><creatorcontrib>Armentano, Maria Francesca</creatorcontrib><creatorcontrib>Carmosino, Monica</creatorcontrib><creatorcontrib>Milella, Luigi</creatorcontrib><creatorcontrib>Russo, Daniela</creatorcontrib><creatorcontrib>Labanca, Fabiana</creatorcontrib><creatorcontrib>Khan, Haroon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faraone, Immacolata</au><au>Sinisgalli, Chiara</au><au>Ostuni, Angela</au><au>Armentano, Maria Francesca</au><au>Carmosino, Monica</au><au>Milella, Luigi</au><au>Russo, Daniela</au><au>Labanca, Fabiana</au><au>Khan, Haroon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2020-05</date><risdate>2020</risdate><volume>155</volume><spage>104689</spage><epage>104689</epage><pages>104689-104689</pages><artnum>104689</artnum><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>[Display omitted]
During the latest decades, the interest on the effectiveness of natural compounds and their impact on human health constantly increased, especially on those demonstrating to be effective on cancer. Molecules coming from nature are currently used in chemotherapy like Taxol, Vincristine or Vinblastine, and several other natural substances have been showed to be active in reducing cancer cell progression and migration. Among them, astaxanthin, a xanthophyll red colored carotenoid, displayed different biological activities including, antinflammatory, antioxidant, proapoptotic, and anticancer effects. It can induce apoptosis through downregulation of antiapoptotic protein (Bcl-2, p-Bad, and survivin) expression and upregulation of proapoptotic ones (Bax/Bad and PARP). Thanks to these mechanisms, it can exert anticancer effects towards colorectal cancer, melanoma, or gastric carcinoma cell lines. Moreover, it possesses antiproliferative activity in many experimental models and enhances the effectiveness of conventional chemotherapic drugs on tumor cells underling its potential future use. This review provides an overview of the current knowledge on the anticancer potential of astaxanthin by modulating several molecular targets. While it has been clearly demonstrated its multitarget activity in the prevention and regression of malignant cells in in vitro or in preclinical investigations, further clinical studies are needed to assess its real potential as anticancer in humans.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32057895</pmid><doi>10.1016/j.phrs.2020.104689</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Cancer prevention Cell cycle Cell Cycle Checkpoints - drug effects Humans Malignancy Neoplasms - drug therapy Proapoptotic Staxanthin Survivina Xanthophylls - pharmacology Xanthophylls - therapeutic use |
| title | Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review |
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