The cytoplasmic polyadenylation element binding protein (CPEB), Orb, is important for dendrite development and neuron fate specification in Drosophila melanogaster

•Drosophila orb functions in dendrite morphogenesis of Class IV da neurons.•orb mutants display defects in neuronal cell fate.•orbMI04761-GFSTF.0 is a hypomorphic allele. Cytoplasmic polyadenylation element binding proteins (CPEBs) are widely conserved proteins that regulate the length of poly(A) ta...

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Veröffentlicht in:	Gene 2020-05, Vol.738, p.144473-144473, Article 144473
Hauptverfasser:	Olesnicky, Eugenia C., Killian, Darrell J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Lineage - physiology Cytoplasm - metabolism Cytoplasmic polyadenylation element binding proteins (CPEBs) Dendrite Dendrites - metabolism Drosophila Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Drosophila Proteins - physiology Gene Expression Regulation, Developmental - genetics Larva - genetics Neurogenesis - physiology Neuron specification Neurons - metabolism Poly(A)-Binding Proteins - metabolism Polyadenylation Posttranscriptional gene regulation RNA-binding proteins RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-Binding Proteins - physiology Transcription Factors - genetics
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