piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B

Piwi-interacting RNAs (piRNAs) dysregulation occurs frequently in extensive cancers. However, there was no report about piRNA expression in esophageal cancer (EC). In this study, the expression levels of piR-823 and DNMT1, DNMT3A, DNMT3B were detected in 54 pairs of ESCC tissues and adjacent normal...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2020-04, Vol.216 (4), p.152848-152848, Article 152848
Hauptverfasser:	Su, Jing-Fen, Zhao, Fang, Gao, Zhao-Wei, Hou, Yong-Jie, Li, Yuan-Yuan, Duan, Li-Juan, Lun, Shu-Min, Yang, Hai-Jun, Li, Jun-Kuo, Dai, Ning-Tao, Shen, Fang-Fang, Zhou, Fu-You
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - genetics DNA (Cytosine-5-)-Methyltransferases - biosynthesis DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation DNA Methyltransferase 3B DNA methyltransferases Epigenetic regulation Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Female Gene Expression Regulation, Neoplastic - genetics Humans Lymph node metastasis Male Middle Aged piR-823 RNA, Small Interfering - genetics RNA, Small Interfering - metabolism
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