Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits

Both diabetes mellitus (DM) and atrial fibrillation (AF) are usually associated with enhanced inflammatory response. The effect of the “NACHT, LRR and PYD domain containing protein 3” (NLRP3)-inflammasome/caspase-1/galectin-3 pathway and the potential benefits of NLRP3-inflammasome inhibitor glibenc...

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Veröffentlicht in:	Journal of cardiovascular translational research 2020-10, Vol.13 (5), p.731-740
Hauptverfasser:	Wu, Xiaohan, Liu, Yang, Tu, Daimiao, Liu, Xianjian, Niu, Shulin, Suo, Ya, Liu, Tong, Li, Guangping, Liu, Changle
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Anti-Inflammatory Agents - pharmacology Atrial Fibrillation - etiology Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Atrial Fibrillation - prevention & control Atrial Function, Left - drug effects Atrial Remodeling - drug effects Biomedical Engineering and Bioengineering Biomedicine Cardiology Caspase 1 - metabolism Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Fibrosis Galectin 3 - metabolism Glyburide - pharmacology Heart Atria - drug effects Heart Atria - metabolism Heart Atria - physiopathology Heart Rate Human Genetics Inflammasomes - antagonists & inhibitors Inflammasomes - metabolism Isolated Heart Preparation Male Medicine Medicine & Public Health NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original Article Rabbits Signal Transduction
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