Severe Hypoxemia Prevents Spontaneous and Naloxone-induced Breathing Recovery after Fentanyl Overdose in Awake and Sedated Rats

BACKGROUND:As severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl overdose-induced apnea on (1) autoresuscitation and (2) the antidotal effects of naloxone. M...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2020-05, Vol.132 (5), p.1138-1150
Hauptverfasser:	Haouzi, Philippe, Guck, Daniel, McCann, Marissa, Sternick, Molly, Sonobe, Takashi, Tubbs, Nicole
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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