Synthesis of the Aminovinylcysteine-Containing C‑Terminal Macrocycle of the Linaridins

N-Phthalimido-d-cysteine allyl ester was S-alkylated with 2-iodoethanol. The derived β-thioaldehyde was condensed with Nα-tetrachlorophthalimidovalinamide to afford a Z-thioenamide. Removal of the tetrachlorophthalimido protecting group and homologation with N-Boc-l-leucine afforded the linear tripe...

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Veröffentlicht in:	Organic letters 2020-03, Vol.22 (5), p.1874-1877
Hauptverfasser:	Lutz, Joshua A, Taylor, Carol M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriocins - chemical synthesis Bacteriocins - chemistry Cyclization Cysteine - analogs & derivatives Cysteine - chemical synthesis Cysteine - chemistry Molecular Structure Peptides - chemistry Peptides - metabolism
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