Analyses of High-Risk Factors for Cervical Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma and Establishment of Nomogram Prediction Model
Laryngeal squamous cell carcinoma (LSCC) is one of the most common laryngeal tumors, and its incidence is increasing yearly; however, whether lymph node dissection should be performed during surgery remains unclear. We retrospectively analyzed the clinical and pathological data of 246 cases of LSCC...
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| Veröffentlicht in: | Ear, nose, & throat journal nose, & throat journal, 2021-09, Vol.100 (5_suppl), p.657S-662S |
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| creator | Chen, Lu-ying Weng, Wei-bin Wang, Wen Chen, Jian-fu |
| description | Laryngeal squamous cell carcinoma (LSCC) is one of the most common laryngeal tumors, and its incidence is increasing yearly; however, whether lymph node dissection should be performed during surgery remains unclear. We retrospectively analyzed the clinical and pathological data of 246 cases of LSCC and developed a nomogram for the prediction of lymph node metastasis (LNM) of LSCC. The predictive performance and consistency of the model were evaluated using the consistency coefficient (C-index) and calibration curve, respectively. Among 246 cases of LSCC, 52 cases had metastasis with a positivity rate of 21.14%. Multivariate analyses showed that dysphagia, clinical T stage, and pathological differentiation were independent risk factors for LNM in LSCC. The accuracy of the contour map used to predict the risk for LNM was 0.809. Overall, this nomogram model can be used to evaluate LNM in patients with LSCC before surgery to decide whether to conduct neck dissection and improve patient prognosis. |
| doi_str_mv | 10.1177/0145561320901613 |
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We retrospectively analyzed the clinical and pathological data of 246 cases of LSCC and developed a nomogram for the prediction of lymph node metastasis (LNM) of LSCC. The predictive performance and consistency of the model were evaluated using the consistency coefficient (C-index) and calibration curve, respectively. Among 246 cases of LSCC, 52 cases had metastasis with a positivity rate of 21.14%. Multivariate analyses showed that dysphagia, clinical T stage, and pathological differentiation were independent risk factors for LNM in LSCC. The accuracy of the contour map used to predict the risk for LNM was 0.809. 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We retrospectively analyzed the clinical and pathological data of 246 cases of LSCC and developed a nomogram for the prediction of lymph node metastasis (LNM) of LSCC. The predictive performance and consistency of the model were evaluated using the consistency coefficient (C-index) and calibration curve, respectively. Among 246 cases of LSCC, 52 cases had metastasis with a positivity rate of 21.14%. Multivariate analyses showed that dysphagia, clinical T stage, and pathological differentiation were independent risk factors for LNM in LSCC. The accuracy of the contour map used to predict the risk for LNM was 0.809. Overall, this nomogram model can be used to evaluate LNM in patients with LSCC before surgery to decide whether to conduct neck dissection and improve patient prognosis.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Cell Differentiation</subject><subject>Deglutition Disorders</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Larynx</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neoplasm Staging</subject><subject>Nomograms</subject><subject>Otolaryngology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Throat cancer</subject><issn>0145-5613</issn><issn>1942-7522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kVtr3DAQhUVoSLZp3_MUBHnJi1tJlnx5DEsuhc2FtH02sjzaVWJZG8kO7P_ID84sm7YQKAgGNN85I80h5Jizb5yX5XfGpVIFzwWrGce6R2a8liIrlRCfyGzbzrb9Q_I5pUfG8KLgB-QQBZJLXs_I6_mg-02CRIOl1265yh5ceqKX2owhJmpDpHOIL87oni42fr2it6EDegOjTnhcom6gCx03wxIQ-fk8aR-mhKK-p3MdjRuC11QPHb1AQdu7tPIwjNtxt8GHZdSe3kfonBldGOgNuvdfyL7VfYKv7_WI_L68-DW_zhZ3Vz_m54vMSFaOmagUs4Z3RW1l3THBbAtdCZWSQvJKtEozDaCttUpxbvICeahY20rLC2NMfkTOdr7rGJ4nSGPjXTL4cj0AfqIRucpVWdWVQPT0A_oYpoi7Q0oVuahyWRdIsR1lYkgpgm3W0XncTsNZs02s-ZgYSk7ejafWQ_dX8CciBLIdkPQS_k39r-EbgvyeXw</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Chen, Lu-ying</creator><creator>Weng, Wei-bin</creator><creator>Wang, Wen</creator><creator>Chen, Jian-fu</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Analyses of High-Risk Factors for Cervical Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma and Establishment of Nomogram Prediction Model</title><author>Chen, Lu-ying ; Weng, Wei-bin ; Wang, Wen ; Chen, Jian-fu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-2850fc1d69f49d020fbed7e85424182b5a0aeeafff5511c36850e80bb4f16ccc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Cell Differentiation</topic><topic>Deglutition Disorders</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>Laryngeal cancer</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Larynx</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neoplasm Staging</topic><topic>Nomograms</topic><topic>Otolaryngology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Skin cancer</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Lu-ying</creatorcontrib><creatorcontrib>Weng, Wei-bin</creatorcontrib><creatorcontrib>Wang, Wen</creatorcontrib><creatorcontrib>Chen, Jian-fu</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Ear, nose, & throat journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Lu-ying</au><au>Weng, Wei-bin</au><au>Wang, Wen</au><au>Chen, Jian-fu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analyses of High-Risk Factors for Cervical Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma and Establishment of Nomogram Prediction Model</atitle><jtitle>Ear, nose, & throat journal</jtitle><addtitle>Ear Nose Throat J</addtitle><date>2021-09</date><risdate>2021</risdate><volume>100</volume><issue>5_suppl</issue><spage>657S</spage><epage>662S</epage><pages>657S-662S</pages><issn>0145-5613</issn><eissn>1942-7522</eissn><abstract>Laryngeal squamous cell carcinoma (LSCC) is one of the most common laryngeal tumors, and its incidence is increasing yearly; however, whether lymph node dissection should be performed during surgery remains unclear. We retrospectively analyzed the clinical and pathological data of 246 cases of LSCC and developed a nomogram for the prediction of lymph node metastasis (LNM) of LSCC. The predictive performance and consistency of the model were evaluated using the consistency coefficient (C-index) and calibration curve, respectively. Among 246 cases of LSCC, 52 cases had metastasis with a positivity rate of 21.14%. Multivariate analyses showed that dysphagia, clinical T stage, and pathological differentiation were independent risk factors for LNM in LSCC. The accuracy of the contour map used to predict the risk for LNM was 0.809. Overall, this nomogram model can be used to evaluate LNM in patients with LSCC before surgery to decide whether to conduct neck dissection and improve patient prognosis.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>32041419</pmid><doi>10.1177/0145561320901613</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis of Variance Carcinoma, Squamous Cell - secondary Cell Differentiation Deglutition Disorders Female Health risks Humans Laryngeal cancer Laryngeal Neoplasms - pathology Larynx Lymph Node Excision Lymphatic Metastasis Lymphatic system Male Metastasis Middle Aged Neck Neoplasm Staging Nomograms Otolaryngology Retrospective Studies Risk Factors Skin cancer Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology Throat cancer |
| title | Analyses of High-Risk Factors for Cervical Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma and Establishment of Nomogram Prediction Model |
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