Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy
Here, we show that the development of nuclei and subsequent growth of a molecular organic crystal system can be induced by electron beam irradiation by exploiting the radiation chemistry of the carrier solvent. The technique of Liquid Cell Electron Microscopy was used to probe the crystal growth of...
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| Veröffentlicht in: | Nanoscale 2020-02, Vol.12 (7), p.4636-4644 |
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| creator | Cookman, Jennifer Hamilton, Victoria Price, Louise S Hall, Simon R Bangert, Ursel |
| description | Here, we show that the development of nuclei and subsequent growth of a molecular organic crystal system can be induced by electron beam irradiation by exploiting the radiation chemistry of the carrier solvent. The technique of Liquid Cell Electron Microscopy was used to probe the crystal growth of flufenamic acid; a current commercialised active pharmaceutical ingredient. This work demonstrates liquid phase electron microscopy analysis as an essential tool for assessing pharmaceutical crystal growth in their native environment while giving insight into polymorph identification of nano-crystals at their very inception. Possible mechanisms of crystal nucleation due to the electron beam with a focus on radiolysis are discussed along with the innovations this technique offers to the study of pharmaceutical crystals and other low contrast materials. |
| doi_str_mv | 10.1039/c9nr08126g |
| format | Article |
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| ispartof | Nanoscale, 2020-02, Vol.12 (7), p.4636-4644 |
| issn | 2040-3364 2040-3372 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Commercialization Crystal growth Crystals Electron beams Electron irradiation Electron microscopy Liquid phases Microscopy Nanocrystals Nucleation Organic chemistry Organic crystals Pharmaceuticals Radiation chemistry Radiolysis |
| title | Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy |
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