Asymmetric Synthesis of Rugulotrosin A

Asymmetric Synthesis of Rugulotrosin A

A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetr...

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Veröffentlicht in:Organic letters 2020-02, Vol.22 (4), p.1485-1489
Hauptverfasser: Chen, Jianhua, Li, Yayue, Xiao, Zheming, He, Haibing, Gao, Shuanhu
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container_issue 4
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container_title Organic letters
container_volume 22
creator Chen, Jianhua
Li, Yayue
Xiao, Zheming
He, Haibing
Gao, Shuanhu
description A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.
doi_str_mv 10.1021/acs.orglett.0c00063
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title Asymmetric Synthesis of Rugulotrosin A
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