Rostral ventrolateral medulla neuron activity is suppressed by Klotho and stimulated by FGF23 in newborn Wistar rats

Hypertension often occurs in patients with chronic kidney disease (CKD). Considering the decrease in serum Klotho and increase in serum FGF23 levels in such patients, decreased Klotho and increased FGF23 levels were thought to be associated with hypertension. Presympathetic neurons at the rostral ve...

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Veröffentlicht in:	Autonomic neuroscience 2020-03, Vol.224, p.102640-102640, Article 102640
Hauptverfasser:	Oshima, Naoki, Onimaru, Hiroshi, Yamagata, Akira, Ito, Seigo, Imakiire, Toshihiko, Kumagai, Hiroo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Animals, Newborn FGF23 FGFR1 Fibroblast Growth Factors - pharmacology Glucuronidase - pharmacology Hypertension - physiopathology Klotho Medulla Oblongata - drug effects Membrane Potentials - drug effects Na+/K+-ATPase Neurons - drug effects Neurons - physiology Rats, Wistar RVLM neurons Spinal Cord - drug effects Spinal Cord - physiopathology Sympathetic Nervous System - physiopathology
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