4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species

Renal fibrosis is an inevitable course of all kinds of progressive chronic kidney disease (CKD). Itaconic acid is an endogenous metabolite that has shown anti-inflammatory and antioxidant effects. 4-octyl itaconate (OI), a derivative of itaconic acid with higher fat solubility, can penetrate the cel...

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Veröffentlicht in:	European journal of pharmacology 2020-04, Vol.873, p.172989-172989, Article 172989
Hauptverfasser:	Tian, Feng, Wang, Zhe, He, Junqiu, Zhang, Zhihao, Tan, Ninghua
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Octyl itaconate Autophagy CKD Life Sciences & Biomedicine Pharmacology & Pharmacy Reactive oxygen species Renal fibrosis Science & Technology TGF-β/Smad
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