CSB6B prevents β-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-κB and NLRP3 in microglia cells

•CSB6B inhibits neuroinflammation in Aβ and LPS treated BV2 microglia cells.•CSB6B prevents cognitive impairments and neuroinflammation in Aβ-treated mice.•CSB6B inhibits NF-κB andrestrainedthe activation of NLRP3. Pathological β-amyloid (Aβ)-induced microglial activation could cause chronic neuroin...

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Veröffentlicht in:	International immunopharmacology 2020-04, Vol.81, p.106263-106263, Article 106263
Hauptverfasser:	Yan, Sicheng, Xuan, Zhenquan, Yang, Mengxiang, Wang, Chuang, Tao, Tao, Wang, Qinwen, Cui, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - immunology Analgesics Animals Anti-Inflammatory Agents - therapeutic use Arginase Biocompatibility Cell Line Cell viability Chicago sky blue 6B Cognitive ability Cognitive Dysfunction - drug therapy Cytokines Cytokines - metabolism Gene expression Hippocampus Humans IL-1β Inflammation Inflammation Mediators - metabolism Inhibition (psychology) Interleukins Lipopolysaccharides Mice Mice, Inbred ICR Microglia Microglia - metabolism Microglia - pathology Microglia cells Neurodegenerative diseases Neurogenic Inflammation - drug therapy Neuroinflammation Neurons Neurons - metabolism Neurons - pathology NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Pain Phenotypes Pyrin protein Rodents Toxicity Trypan Blue - therapeutic use Tumor necrosis factor-α β-Amyloid
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