Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes

Gomisin A (G.A), a lignan compound extracted from the fruits of Schisandra chinensis, is known to exert anti-tumor effects on hepatocarcinoma and colorectal cancer cells. Suppression of proliferation and metastatic abilities of cancer cells are some effective cancer treatment methods. The objective...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2020-03, Vol.68, p.153147-153147, Article 153147
Hauptverfasser:	Han, Yo-Han, Mun, Jeong-Geon, Jeon, Hee Dong, Park, Jinbong, Kee, Ji-Ye, Hong, Seung-Heon
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cell cycle arrest Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cyclooctanes - pharmacology Dioxoles - pharmacology Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Gomisin A Humans Lignans - pharmacology Lung Neoplasms - drug therapy Lung Neoplasms - secondary MAP Kinase Kinase 4 - metabolism Melanoma Melanoma - drug therapy Melanoma - metabolism Melanoma - pathology Metastasis Mice, Inbred C57BL Xenograft Model Antitumor Assays
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