Sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions

The sympathetic nervous system (SNS) activates cAMP signaling and promotes trophic effects on brown adipose tissue (BAT) through poorly understood mechanisms. Because norepinephrine has been found to induce antiproteolytic effects on muscle and heart, we hypothesized that the SNS could inhibit autop...

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Veröffentlicht in:	Journal of applied physiology (1985) 2020-04, Vol.128 (4), p.855-871
Hauptverfasser:	Przygodda, Franciele, Lautherbach, Natalia, Buzelle, Samyra Lopes, Goncalves, Dawit Albieiro, Assis, Ana Paula, Paula-Gomes, Sílvia, Garófalo, Maria Antonieta Rissato, Heck, Lilian Carmo, Matsuo, Flávia Sayuri, Mota, Ryerson Fonseca, Osako, Mariana Kiomy, Kettelhut, Isis C, Navegantes, Luiz C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose tissue (brown) AKT protein Atrophy Autophagy Body fat Cardiac muscle Cold Cold stimuli Cyclic AMP Denervation Forkhead protein Gene expression Hypertrophy Innervation Kinases mRNA Muscles Norepinephrine Phagocytosis Phosphorylation Post-transcription Protein biosynthesis Protein synthesis Proteins Puromycin Rapamycin Sympathetic nervous system Thermogenesis TOR protein
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