Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia
Purpose To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia. Methods This cross‐sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherenc...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2020-09, Vol.98 (6), p.e709-e714 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Wu, Qiuyan Chen, Qi Lin, Bing Huang, Shenghai Wang, Yuanyuan Zhang, Lingmin Lin, Huiling Wang, Jianhua Lu, Fan Shen, Meixiao |
| description | Purpose
To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.
Methods
This cross‐sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was used to quantify the thickness of ganglion cell complex (GCC), inner nuclear layer and outer plexiform layer (INOPL), outer retinal layer (ORL) and choroid layer (ChL). Optical coherence tomography angiography was used to quantify the superficial vessel density (SVD) and deep vessel density (DVD). Retinal light sensitivity (RLS) was measured by microperimetry‐1 (MP1). The inner ring (1–1.75 mm), the outer ring (1.75–2.5 mm) and the whole ring (1–2.5 mm) around the macula were analysed and compared between the two groups. Pearson correlation analysis was performed to analyse the relationship among them.
Results
In the highly myopic group, the thinning of retinal/choroidal thickness and the decrease in retinal vessel density and RLS were found when compared to the emmetropia or low myopia (p 0.05), but DVD showed a negative correlation with ORL (r = −0.474, p = 0.007).
Conclusion
Early visual field defects in highly myopic eyes may be influenced by the ORL loss and defect of choroidal circulation. The deep retinal microvascular network may have a compensatory action in the hypoxic setting of high myopia. |
| doi_str_mv | 10.1111/aos.14372 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2352632251</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2435510245</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3882-1526d59d5370ee72e22d013572f01ab527bd9805610ff57b7e43294d414d212b3</originalsourceid><addsrcrecordid>eNp10U1LwzAcBvAgis7pwS8gAS8KdstL03THMXyDgeALeCtpk9q4NJlJu7Fvb3TqQTCXBPLjCf88AJxgNMJxjYULI5xSTnbAAHPGEsqzfPf3zF4OwGEIbwhlOMvSfXBACaJogtAA2AdlRKedDY1eBihaZ1-hV522woyrxnmnpTCwa3S1sCqEy59L2OrKu5UIVW-Eh1Z1a-cXUFgJVzr0EdRaGQm1hY1-bWC7cUstjsBeLUxQx9_7EDxfXz3NbpP5_c3dbDpPKprnJMGMZJJNJKMcKcWJIkQiTBknNcKiZISXcpIjlmFU14yXXKWUTFKZ4lQSTEo6BOfb3KV3770KXdHqUCljhFWuDwWh8QVKCMORnv2hb673ccKoUsoYRiRlUV1sVRw6BK_qYul1K_ymwKj4LKGIJRRfJUR7-p3Yl62Sv_Ln1yMYb8FaG7X5P6mY3j9uIz8AbZCQlg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435510245</pqid></control><display><type>article</type><title>Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wu, Qiuyan ; Chen, Qi ; Lin, Bing ; Huang, Shenghai ; Wang, Yuanyuan ; Zhang, Lingmin ; Lin, Huiling ; Wang, Jianhua ; Lu, Fan ; Shen, Meixiao</creator><creatorcontrib>Wu, Qiuyan ; Chen, Qi ; Lin, Bing ; Huang, Shenghai ; Wang, Yuanyuan ; Zhang, Lingmin ; Lin, Huiling ; Wang, Jianhua ; Lu, Fan ; Shen, Meixiao</creatorcontrib><description>Purpose
To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.
Methods
This cross‐sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was used to quantify the thickness of ganglion cell complex (GCC), inner nuclear layer and outer plexiform layer (INOPL), outer retinal layer (ORL) and choroid layer (ChL). Optical coherence tomography angiography was used to quantify the superficial vessel density (SVD) and deep vessel density (DVD). Retinal light sensitivity (RLS) was measured by microperimetry‐1 (MP1). The inner ring (1–1.75 mm), the outer ring (1.75–2.5 mm) and the whole ring (1–2.5 mm) around the macula were analysed and compared between the two groups. Pearson correlation analysis was performed to analyse the relationship among them.
Results
In the highly myopic group, the thinning of retinal/choroidal thickness and the decrease in retinal vessel density and RLS were found when compared to the emmetropia or low myopia (p < 0.05). Decreased RLS was correlated with decreased ORL thickness (r = −0.469, p = 0.008) and choroid thickness (r = 0.398, p = 0.030). There was no correlation between retinal microvascular network parameters and RLS (p > 0.05), but DVD showed a negative correlation with ORL (r = −0.474, p = 0.007).
Conclusion
Early visual field defects in highly myopic eyes may be influenced by the ORL loss and defect of choroidal circulation. The deep retinal microvascular network may have a compensatory action in the hypoxic setting of high myopia.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14372</identifier><identifier>PMID: 32030900</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Angiography ; Correlation analysis ; Eye ; high myopia ; Hypoxia ; Microvasculature ; Myopia ; optical coherence tomography ; outer retinal layer ; Retina ; retinal microvascular network ; Tomography ; Visual field</subject><ispartof>Acta ophthalmologica (Oxford, England), 2020-09, Vol.98 (6), p.e709-e714</ispartof><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-1526d59d5370ee72e22d013572f01ab527bd9805610ff57b7e43294d414d212b3</citedby><cites>FETCH-LOGICAL-c3882-1526d59d5370ee72e22d013572f01ab527bd9805610ff57b7e43294d414d212b3</cites><orcidid>0000-0003-4523-2211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.14372$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.14372$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32030900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Qiuyan</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Lin, Bing</creatorcontrib><creatorcontrib>Huang, Shenghai</creatorcontrib><creatorcontrib>Wang, Yuanyuan</creatorcontrib><creatorcontrib>Zhang, Lingmin</creatorcontrib><creatorcontrib>Lin, Huiling</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Lu, Fan</creatorcontrib><creatorcontrib>Shen, Meixiao</creatorcontrib><title>Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.
Methods
This cross‐sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was used to quantify the thickness of ganglion cell complex (GCC), inner nuclear layer and outer plexiform layer (INOPL), outer retinal layer (ORL) and choroid layer (ChL). Optical coherence tomography angiography was used to quantify the superficial vessel density (SVD) and deep vessel density (DVD). Retinal light sensitivity (RLS) was measured by microperimetry‐1 (MP1). The inner ring (1–1.75 mm), the outer ring (1.75–2.5 mm) and the whole ring (1–2.5 mm) around the macula were analysed and compared between the two groups. Pearson correlation analysis was performed to analyse the relationship among them.
Results
In the highly myopic group, the thinning of retinal/choroidal thickness and the decrease in retinal vessel density and RLS were found when compared to the emmetropia or low myopia (p < 0.05). Decreased RLS was correlated with decreased ORL thickness (r = −0.469, p = 0.008) and choroid thickness (r = 0.398, p = 0.030). There was no correlation between retinal microvascular network parameters and RLS (p > 0.05), but DVD showed a negative correlation with ORL (r = −0.474, p = 0.007).
Conclusion
Early visual field defects in highly myopic eyes may be influenced by the ORL loss and defect of choroidal circulation. The deep retinal microvascular network may have a compensatory action in the hypoxic setting of high myopia.</description><subject>Angiography</subject><subject>Correlation analysis</subject><subject>Eye</subject><subject>high myopia</subject><subject>Hypoxia</subject><subject>Microvasculature</subject><subject>Myopia</subject><subject>optical coherence tomography</subject><subject>outer retinal layer</subject><subject>Retina</subject><subject>retinal microvascular network</subject><subject>Tomography</subject><subject>Visual field</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10U1LwzAcBvAgis7pwS8gAS8KdstL03THMXyDgeALeCtpk9q4NJlJu7Fvb3TqQTCXBPLjCf88AJxgNMJxjYULI5xSTnbAAHPGEsqzfPf3zF4OwGEIbwhlOMvSfXBACaJogtAA2AdlRKedDY1eBihaZ1-hV522woyrxnmnpTCwa3S1sCqEy59L2OrKu5UIVW-Eh1Z1a-cXUFgJVzr0EdRaGQm1hY1-bWC7cUstjsBeLUxQx9_7EDxfXz3NbpP5_c3dbDpPKprnJMGMZJJNJKMcKcWJIkQiTBknNcKiZISXcpIjlmFU14yXXKWUTFKZ4lQSTEo6BOfb3KV3770KXdHqUCljhFWuDwWh8QVKCMORnv2hb673ccKoUsoYRiRlUV1sVRw6BK_qYul1K_ymwKj4LKGIJRRfJUR7-p3Yl62Sv_Ln1yMYb8FaG7X5P6mY3j9uIz8AbZCQlg</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Wu, Qiuyan</creator><creator>Chen, Qi</creator><creator>Lin, Bing</creator><creator>Huang, Shenghai</creator><creator>Wang, Yuanyuan</creator><creator>Zhang, Lingmin</creator><creator>Lin, Huiling</creator><creator>Wang, Jianhua</creator><creator>Lu, Fan</creator><creator>Shen, Meixiao</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4523-2211</orcidid></search><sort><creationdate>202009</creationdate><title>Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia</title><author>Wu, Qiuyan ; Chen, Qi ; Lin, Bing ; Huang, Shenghai ; Wang, Yuanyuan ; Zhang, Lingmin ; Lin, Huiling ; Wang, Jianhua ; Lu, Fan ; Shen, Meixiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-1526d59d5370ee72e22d013572f01ab527bd9805610ff57b7e43294d414d212b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiography</topic><topic>Correlation analysis</topic><topic>Eye</topic><topic>high myopia</topic><topic>Hypoxia</topic><topic>Microvasculature</topic><topic>Myopia</topic><topic>optical coherence tomography</topic><topic>outer retinal layer</topic><topic>Retina</topic><topic>retinal microvascular network</topic><topic>Tomography</topic><topic>Visual field</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Qiuyan</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Lin, Bing</creatorcontrib><creatorcontrib>Huang, Shenghai</creatorcontrib><creatorcontrib>Wang, Yuanyuan</creatorcontrib><creatorcontrib>Zhang, Lingmin</creatorcontrib><creatorcontrib>Lin, Huiling</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Lu, Fan</creatorcontrib><creatorcontrib>Shen, Meixiao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Qiuyan</au><au>Chen, Qi</au><au>Lin, Bing</au><au>Huang, Shenghai</au><au>Wang, Yuanyuan</au><au>Zhang, Lingmin</au><au>Lin, Huiling</au><au>Wang, Jianhua</au><au>Lu, Fan</au><au>Shen, Meixiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2020-09</date><risdate>2020</risdate><volume>98</volume><issue>6</issue><spage>e709</spage><epage>e714</epage><pages>e709-e714</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.
Methods
This cross‐sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was used to quantify the thickness of ganglion cell complex (GCC), inner nuclear layer and outer plexiform layer (INOPL), outer retinal layer (ORL) and choroid layer (ChL). Optical coherence tomography angiography was used to quantify the superficial vessel density (SVD) and deep vessel density (DVD). Retinal light sensitivity (RLS) was measured by microperimetry‐1 (MP1). The inner ring (1–1.75 mm), the outer ring (1.75–2.5 mm) and the whole ring (1–2.5 mm) around the macula were analysed and compared between the two groups. Pearson correlation analysis was performed to analyse the relationship among them.
Results
In the highly myopic group, the thinning of retinal/choroidal thickness and the decrease in retinal vessel density and RLS were found when compared to the emmetropia or low myopia (p < 0.05). Decreased RLS was correlated with decreased ORL thickness (r = −0.469, p = 0.008) and choroid thickness (r = 0.398, p = 0.030). There was no correlation between retinal microvascular network parameters and RLS (p > 0.05), but DVD showed a negative correlation with ORL (r = −0.474, p = 0.007).
Conclusion
Early visual field defects in highly myopic eyes may be influenced by the ORL loss and defect of choroidal circulation. The deep retinal microvascular network may have a compensatory action in the hypoxic setting of high myopia.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32030900</pmid><doi>10.1111/aos.14372</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4523-2211</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete |
| subjects | Angiography Correlation analysis Eye high myopia Hypoxia Microvasculature Myopia optical coherence tomography outer retinal layer Retina retinal microvascular network Tomography Visual field |
| title | Relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia |
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