Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-02, Vol.52 (2), p.342-356.e6
Hauptverfasser:	McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - immunology Autoimmune diseases autoimmunity Autoimmunity - genetics Autoimmunity - immunology Cell activation Cell culture Central nervous system Central Nervous System - immunology Chemokines Clinical trials Cytokines Defects Disease Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Experimental allergic encephalomyelitis experimental autoimmune encephalomyelitis Health services Helper cells IL-17 IL-1β Inflammation inflammatory monocyte Interleukin 1 Interleukin 17 Interleukin 23 Interleukin-17 - antagonists & inhibitors Interleukin-17 - deficiency Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-1beta - immunology Interleukin-1beta - metabolism Interleukin-23 - immunology Interleukin-23 - metabolism Intraepithelial Lymphocytes - immunology Intraepithelial Lymphocytes - metabolism Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Medical treatment Mice Mice, Inbred C57BL Mice, Knockout Monocytes Monocytes - immunology Monocytes - metabolism Multiple sclerosis Myeloid cells Myeloid Cells - immunology Myeloid Cells - metabolism neutrophil Neutrophils Neutrophils - immunology Neutrophils - metabolism Priming Psoriasis Th17 cells Th17 Cells - immunology Th17 Cells - metabolism Tumor necrosis factor-TNF γδ T cells
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