Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy
Background The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study as...
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Veröffentlicht in: | International forum of allergy & rhinology 2020-03, Vol.10 (3), p.278-281 |
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creator | Papagiannopoulos, Peter Tong, Ching Lick Kuan, Edward C. Tajudeen, Bobby A. Yver, Christina M. Kohanski, Michael A. Cohen, Noam A. Kennedy, David W. Palmer, James N. Adappa, Nithin D. |
description | Background
The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors.
Methods
A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor.
Results
Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184).
Conclusion
In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis. |
doi_str_mv | 10.1002/alr.22484 |
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The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors.
Methods
A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor.
Results
Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184).
Conclusion
In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.22484</identifier><identifier>PMID: 32022422</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>anterior skull‐base ; chronic rhinosinusitis ; Comparative analysis ; Computed tomography ; Diagnosis, Differential ; endoscopic skull‐base surgery ; Head & neck cancer ; Humans ; imaging ; Inflammation ; Inflammatory diseases ; Malignancy ; Papilloma ; Papilloma, Inverted - complications ; Papilloma, Inverted - diagnostic imaging ; Papilloma, Inverted - pathology ; Paranasal sinus ; Paranasal Sinus Neoplasms - complications ; Paranasal Sinus Neoplasms - diagnostic imaging ; Paranasal Sinus Neoplasms - pathology ; Retrospective Studies ; Rhinitis ; Severity of Illness Index ; Sinus ; Sinuses ; Sinusitis ; Sinusitis - complications ; Sinusitis - diagnostic imaging ; Sinusitis - pathology ; skull base ; Tertiary Care Centers ; Tomography, X-Ray Computed ; Tumorigenesis ; Tumors</subject><ispartof>International forum of allergy & rhinology, 2020-03, Vol.10 (3), p.278-281</ispartof><rights>2020 ARS‐AAOA, LLC</rights><rights>2020 ARS-AAOA, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-b93cacb28fecfc0baecff67dac2384b89020a55017857e5560963fe01c4568033</citedby><cites>FETCH-LOGICAL-c3534-b93cacb28fecfc0baecff67dac2384b89020a55017857e5560963fe01c4568033</cites><orcidid>0000-0002-4209-9980 ; 0000-0003-3475-0718 ; 0000-0002-4471-5134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.22484$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.22484$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32022422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papagiannopoulos, Peter</creatorcontrib><creatorcontrib>Tong, Ching Lick</creatorcontrib><creatorcontrib>Kuan, Edward C.</creatorcontrib><creatorcontrib>Tajudeen, Bobby A.</creatorcontrib><creatorcontrib>Yver, Christina M.</creatorcontrib><creatorcontrib>Kohanski, Michael A.</creatorcontrib><creatorcontrib>Cohen, Noam A.</creatorcontrib><creatorcontrib>Kennedy, David W.</creatorcontrib><creatorcontrib>Palmer, James N.</creatorcontrib><creatorcontrib>Adappa, Nithin D.</creatorcontrib><title>Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Background
The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors.
Methods
A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor.
Results
Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184).
Conclusion
In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.</description><subject>anterior skull‐base</subject><subject>chronic rhinosinusitis</subject><subject>Comparative analysis</subject><subject>Computed tomography</subject><subject>Diagnosis, Differential</subject><subject>endoscopic skull‐base surgery</subject><subject>Head & neck cancer</subject><subject>Humans</subject><subject>imaging</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Malignancy</subject><subject>Papilloma</subject><subject>Papilloma, Inverted - complications</subject><subject>Papilloma, Inverted - diagnostic imaging</subject><subject>Papilloma, Inverted - pathology</subject><subject>Paranasal sinus</subject><subject>Paranasal Sinus Neoplasms - complications</subject><subject>Paranasal Sinus Neoplasms - diagnostic imaging</subject><subject>Paranasal Sinus Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Rhinitis</subject><subject>Severity of Illness Index</subject><subject>Sinus</subject><subject>Sinuses</subject><subject>Sinusitis</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - diagnostic imaging</subject><subject>Sinusitis - pathology</subject><subject>skull base</subject><subject>Tertiary Care Centers</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctKxDAUBuAgioq68AUk4EYX4-TapksRbzAgiK7LaZrORNKkJh2HeXszjroQzOYk4cvPIQehU0quKCFsCi5eMSaU2EGHjAg2KSoldn_3ZXGATlJ6I3lJKiUt99EBZyQ_YewQhUf_YeJoWjzAYJ0LPWCbMKQUtIXN_cqOCzyPJh8ijtDaMI8wLKzG1ncO-h7GENe4tclAMnhcgMdhXGScrA8eEjjcg7NzD16vj9FeBy6Zk-96hF7vbl9uHiazp_vHm-vZRHPJxaSpuAbdMNUZ3WnSQC5dUbagGVeiURVhBKQktFSyNFIWpCp4ZwjVQhaKcH6ELra5QwzvS5PGurdJG-fAm7BMNeOSCkVFRTI9_0PfwjL63F1WquSkqJjK6nKrdAwpRdPVQ7Q9xHVNSb0ZRJ0HUX8NItuz78Rl05v2V_58ewbTLVhZZ9b_J9XXs-dt5Ce4e5MX</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Papagiannopoulos, Peter</creator><creator>Tong, Ching Lick</creator><creator>Kuan, Edward C.</creator><creator>Tajudeen, Bobby A.</creator><creator>Yver, Christina M.</creator><creator>Kohanski, Michael A.</creator><creator>Cohen, Noam A.</creator><creator>Kennedy, David W.</creator><creator>Palmer, James N.</creator><creator>Adappa, Nithin D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4209-9980</orcidid><orcidid>https://orcid.org/0000-0003-3475-0718</orcidid><orcidid>https://orcid.org/0000-0002-4471-5134</orcidid></search><sort><creationdate>202003</creationdate><title>Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy</title><author>Papagiannopoulos, Peter ; Tong, Ching Lick ; Kuan, Edward C. ; Tajudeen, Bobby A. ; Yver, Christina M. ; Kohanski, Michael A. ; Cohen, Noam A. ; Kennedy, David W. ; Palmer, James N. ; Adappa, Nithin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-b93cacb28fecfc0baecff67dac2384b89020a55017857e5560963fe01c4568033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>anterior skull‐base</topic><topic>chronic rhinosinusitis</topic><topic>Comparative analysis</topic><topic>Computed tomography</topic><topic>Diagnosis, Differential</topic><topic>endoscopic skull‐base surgery</topic><topic>Head & neck cancer</topic><topic>Humans</topic><topic>imaging</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Malignancy</topic><topic>Papilloma</topic><topic>Papilloma, Inverted - complications</topic><topic>Papilloma, Inverted - diagnostic imaging</topic><topic>Papilloma, Inverted - pathology</topic><topic>Paranasal sinus</topic><topic>Paranasal Sinus Neoplasms - complications</topic><topic>Paranasal Sinus Neoplasms - diagnostic imaging</topic><topic>Paranasal Sinus Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Rhinitis</topic><topic>Severity of Illness Index</topic><topic>Sinus</topic><topic>Sinuses</topic><topic>Sinusitis</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - diagnostic imaging</topic><topic>Sinusitis - pathology</topic><topic>skull base</topic><topic>Tertiary Care Centers</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papagiannopoulos, Peter</creatorcontrib><creatorcontrib>Tong, Ching Lick</creatorcontrib><creatorcontrib>Kuan, Edward C.</creatorcontrib><creatorcontrib>Tajudeen, Bobby A.</creatorcontrib><creatorcontrib>Yver, Christina M.</creatorcontrib><creatorcontrib>Kohanski, Michael A.</creatorcontrib><creatorcontrib>Cohen, Noam A.</creatorcontrib><creatorcontrib>Kennedy, David W.</creatorcontrib><creatorcontrib>Palmer, James N.</creatorcontrib><creatorcontrib>Adappa, Nithin D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papagiannopoulos, Peter</au><au>Tong, Ching Lick</au><au>Kuan, Edward C.</au><au>Tajudeen, Bobby A.</au><au>Yver, Christina M.</au><au>Kohanski, Michael A.</au><au>Cohen, Noam A.</au><au>Kennedy, David W.</au><au>Palmer, James N.</au><au>Adappa, Nithin D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>10</volume><issue>3</issue><spage>278</spage><epage>281</epage><pages>278-281</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Background
The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors.
Methods
A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor.
Results
Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184).
Conclusion
In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32022422</pmid><doi>10.1002/alr.22484</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-4209-9980</orcidid><orcidid>https://orcid.org/0000-0003-3475-0718</orcidid><orcidid>https://orcid.org/0000-0002-4471-5134</orcidid></addata></record> |
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subjects | anterior skull‐base chronic rhinosinusitis Comparative analysis Computed tomography Diagnosis, Differential endoscopic skull‐base surgery Head & neck cancer Humans imaging Inflammation Inflammatory diseases Malignancy Papilloma Papilloma, Inverted - complications Papilloma, Inverted - diagnostic imaging Papilloma, Inverted - pathology Paranasal sinus Paranasal Sinus Neoplasms - complications Paranasal Sinus Neoplasms - diagnostic imaging Paranasal Sinus Neoplasms - pathology Retrospective Studies Rhinitis Severity of Illness Index Sinus Sinuses Sinusitis Sinusitis - complications Sinusitis - diagnostic imaging Sinusitis - pathology skull base Tertiary Care Centers Tomography, X-Ray Computed Tumorigenesis Tumors |
title | Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy |
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