Acetaminophen‐induced hepatotoxicity of cultured hepatocytes depends on timing of isolation from light‐cycle controlled mice

Most physiological changes follow a daily cycle in animals because their circadian rhythm is adjusted to and synchronized with sunlight. In particular, the circadian rhythm affects liver functions, including pharmacokinetics and metabolism. The influence of circadian rhythm has not been included in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2020-04, Vol.25 (4), p.257-269
Hauptverfasser:	Moriya, Koji, Tamai, Miho, Koga, Takumi, Tanaka, Toshiaki, Tagawa, Yoh‐ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen acetaminophen‐induced hepatotoxicity Analgesics Cell culture Circadian rhythm Circadian rhythms culture model Drug metabolism Glutathione hepatic function Hepatocytes Hepatotoxicity Liver Metabolism Pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!