Neuronal firing modulation by a membrane-targeted photoswitch

Optical technologies allowing modulation of neuronal activity at high spatio-temporal resolution are becoming paramount in neuroscience. In this respect, azobenzene-based photoswitches are promising nanoscale tools for neuronal photostimulation. Here we engineered a light-sensitive azobenzene compou...

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Veröffentlicht in:	Nature nanotechnology 2020-04, Vol.15 (4), p.296-306
Hauptverfasser:	DiFrancesco, Mattia Lorenzo, Lodola, Francesco, Colombo, Elisabetta, Maragliano, Luca, Bramini, Mattia, Paternò, Giuseppe Maria, Baldelli, Pietro, Serra, Mauro Dalla, Lunelli, Lorenzo, Marchioretto, Marta, Grasselli, Giorgio, Cimò, Simone, Colella, Letizia, Fazzi, Daniele, Ortica, Fausto, Vurro, Vito, Eleftheriou, Cyril Giles, Shmal, Dmytro, Maya-Vetencourt, José Fernando, Bertarelli, Chiara, Lanzani, Guglielmo, Benfenati, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	140/125 631/61 639/624 639/638 639/925 Action potential Action Potentials Animals Azo compounds Azo Compounds - chemical synthesis Azo Compounds - chemistry Azo Compounds - metabolism Azo Compounds - pharmacology Capacitance Cell Membrane - metabolism Chemistry and Materials Science Depolarization Dimerization Hippocampus - metabolism Hyperpolarization Ion channels Materials Science Membrane capacitance Membranes Mice Modulation Nanotechnology Nanotechnology and Microengineering Nervous system Neuromodulation Neurons Neurons - metabolism Partitions Temporal resolution Thinning
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