R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels
Purpose Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders. ABCA1 variants have been shown to be associated to these conditions. We sought to test the combined effect of two ABCA1 gene common variants, rs2422493...
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| Veröffentlicht in: | Journal of endocrinological investigation 2020-08, Vol.43 (8), p.1061-1071 |
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| creator | Ochoa-Guzmán, A. Moreno-Macías, H. Guillén-Quintero, D. Chávez-Talavera, O. Ordoñez-Sánchez, M. L. Segura-Kato, Y. Ortíz, V. Díaz-Díaz, E. Muñoz-Hernández, L. García, A. Pérez-Méndez, O. Zentella-Dehesa, A. Aguilar-Salinas, C. A. Tusié-Luna, M. T. |
| description | Purpose
Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders.
ABCA1
variants have been shown to be associated to these conditions. We sought to test the combined effect of two
ABCA1
gene common variants, rs2422493 (− 565C > T) and rs9282541 (R230C) on HDL-c levels and T2D risk.
Methods
Path analysis was conducted in 3,303 Mexican-mestizos to assess the specific contributions of rs2422493 and rs9282541
ABCA1
variants, insulin resistance, waist-to-height ratio (WHtR), and age on HDL-c levels and T2D risk. Participants were classified into four groups according to their
ABCA1
variants carrier status: (i) the reference group carried wild type alleles for both
ABCA1
variants (−/−), (ii) +/– were carriers of rs2422493 but non-carriers of rs9282541, (iii) −/+ for carriers of rs9282541 but not carriers of rs2422493 and (iv) carriers of minor alleles for both SNPs (+/+). Principal components from two previous genome-wide association studies were used to control for ethnicity.
Results
We identified significant indirect effects on T2D risk mediated by HDL-c in groups −/+ and +/+ (
β
= 0.04;
p
= 0.03 and
β
= 0.06;
p
|
| doi_str_mv | 10.1007/s40618-020-01187-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2350903028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2350903028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a5a9f53c82e0512ed859c08dcd8542f6dfe57b8ab8b7076b114416056dfde8663</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiMEoqXwAhzQSFy4hI7txPEelxQoUhESKmfLSSa7rrL2YjstvXGEKyeer0-Cly1_xIHTzMi_75uRv6J4zPA5Q2yOY4WSqRI5lsiYakp1pzhkTR6VUPLuX_1B8SDGC0TRCNXcLw4ERyYXTB4W399zgS10cwLnE9x8-Xbz-Wst6_b4HC5NsMYl8COkNcHyRbtksCJHYCOYGH1vTaIBrmxaQ7reEnAYrOkoUQTr4C19sr1xMauDn1drMA5oHKnPlg4mf0XBuhWcnpyV_dpPFBMFP8FElzTFh8W90UyRHt3Wo-LDq5fn7Wl59u71m3aZJaKpU2lqsxhr0StOWDNOg6oXPaqhz03FRzmMVDedMp3qGmxkx1hVMYl1fhhISSmOimd7323wH-d8g97Y2NM0GUd-jpqLGhcokKuMPv0HvfBzcPk6zSteMc5Q7ii-p_rgYww06m2wGxOuNUO9y03vc9M5N_0zN70TPbm1nrsNDb8lv4LKgNgDcbv7NAp_dv_H9gcI5aMD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424121068</pqid></control><display><type>article</type><title>R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ochoa-Guzmán, A. ; Moreno-Macías, H. ; Guillén-Quintero, D. ; Chávez-Talavera, O. ; Ordoñez-Sánchez, M. L. ; Segura-Kato, Y. ; Ortíz, V. ; Díaz-Díaz, E. ; Muñoz-Hernández, L. ; García, A. ; Pérez-Méndez, O. ; Zentella-Dehesa, A. ; Aguilar-Salinas, C. A. ; Tusié-Luna, M. T.</creator><creatorcontrib>Ochoa-Guzmán, A. ; Moreno-Macías, H. ; Guillén-Quintero, D. ; Chávez-Talavera, O. ; Ordoñez-Sánchez, M. L. ; Segura-Kato, Y. ; Ortíz, V. ; Díaz-Díaz, E. ; Muñoz-Hernández, L. ; García, A. ; Pérez-Méndez, O. ; Zentella-Dehesa, A. ; Aguilar-Salinas, C. A. ; Tusié-Luna, M. T.</creatorcontrib><description>Purpose
Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders.
ABCA1
variants have been shown to be associated to these conditions. We sought to test the combined effect of two
ABCA1
gene common variants, rs2422493 (− 565C > T) and rs9282541 (R230C) on HDL-c levels and T2D risk.
Methods
Path analysis was conducted in 3,303 Mexican-mestizos to assess the specific contributions of rs2422493 and rs9282541
ABCA1
variants, insulin resistance, waist-to-height ratio (WHtR), and age on HDL-c levels and T2D risk. Participants were classified into four groups according to their
ABCA1
variants carrier status: (i) the reference group carried wild type alleles for both
ABCA1
variants (−/−), (ii) +/– were carriers of rs2422493 but non-carriers of rs9282541, (iii) −/+ for carriers of rs9282541 but not carriers of rs2422493 and (iv) carriers of minor alleles for both SNPs (+/+). Principal components from two previous genome-wide association studies were used to control for ethnicity.
Results
We identified significant indirect effects on T2D risk mediated by HDL-c in groups −/+ and +/+ (
β
= 0.04;
p
= 0.03 and
β
= 0.06;
p
< 0.01, respectively) in comparison to the −/− reference group. Low concentrations of HDL-c were directly and significantly associated with increased T2D risk (
β
= −0.70;
p
< 0.01). WHtR, male gender, age, and insulin resistance were also associated with T2D risk (
p
< 0.05). There was no significant direct effect for any of the
ABCA1
groups on T2D risk:
p
= 0.99,
p
= 0.58, and
p
= 0.91 for groups +/–, −/+, and +/+ respectively.
Conclusions
The
ABCA1
rs9282541 (R230C) allele is associated with T2D in Mexicans through its effect on lowering HDL-c levels. This is the first report demonstrating that HDL-c levels act as an intermediate factor between an
ABCA1
variant and T2D.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-020-01187-8</identifier><identifier>PMID: 32016916</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>ABCA1 protein ; Adult ; Alleles ; ATP Binding Cassette Transporter 1 - genetics ; ATP-binding protein ; Biomarkers - analysis ; Cholesterol ; Cholesterol, HDL - blood ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Endocrinology ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomes ; High density lipoprotein ; Humans ; Insulin ; Insulin resistance ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic disorders ; Mexico - epidemiology ; Middle Aged ; Original Article ; Polymorphism, Single Nucleotide ; Prognosis ; Single-nucleotide polymorphism</subject><ispartof>Journal of endocrinological investigation, 2020-08, Vol.43 (8), p.1061-1071</ispartof><rights>Italian Society of Endocrinology (SIE) 2020</rights><rights>Italian Society of Endocrinology (SIE) 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a5a9f53c82e0512ed859c08dcd8542f6dfe57b8ab8b7076b114416056dfde8663</citedby><cites>FETCH-LOGICAL-c375t-a5a9f53c82e0512ed859c08dcd8542f6dfe57b8ab8b7076b114416056dfde8663</cites><orcidid>0000-0003-4478-038X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-020-01187-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-020-01187-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32016916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ochoa-Guzmán, A.</creatorcontrib><creatorcontrib>Moreno-Macías, H.</creatorcontrib><creatorcontrib>Guillén-Quintero, D.</creatorcontrib><creatorcontrib>Chávez-Talavera, O.</creatorcontrib><creatorcontrib>Ordoñez-Sánchez, M. L.</creatorcontrib><creatorcontrib>Segura-Kato, Y.</creatorcontrib><creatorcontrib>Ortíz, V.</creatorcontrib><creatorcontrib>Díaz-Díaz, E.</creatorcontrib><creatorcontrib>Muñoz-Hernández, L.</creatorcontrib><creatorcontrib>García, A.</creatorcontrib><creatorcontrib>Pérez-Méndez, O.</creatorcontrib><creatorcontrib>Zentella-Dehesa, A.</creatorcontrib><creatorcontrib>Aguilar-Salinas, C. A.</creatorcontrib><creatorcontrib>Tusié-Luna, M. T.</creatorcontrib><title>R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders.
ABCA1
variants have been shown to be associated to these conditions. We sought to test the combined effect of two
ABCA1
gene common variants, rs2422493 (− 565C > T) and rs9282541 (R230C) on HDL-c levels and T2D risk.
Methods
Path analysis was conducted in 3,303 Mexican-mestizos to assess the specific contributions of rs2422493 and rs9282541
ABCA1
variants, insulin resistance, waist-to-height ratio (WHtR), and age on HDL-c levels and T2D risk. Participants were classified into four groups according to their
ABCA1
variants carrier status: (i) the reference group carried wild type alleles for both
ABCA1
variants (−/−), (ii) +/– were carriers of rs2422493 but non-carriers of rs9282541, (iii) −/+ for carriers of rs9282541 but not carriers of rs2422493 and (iv) carriers of minor alleles for both SNPs (+/+). Principal components from two previous genome-wide association studies were used to control for ethnicity.
Results
We identified significant indirect effects on T2D risk mediated by HDL-c in groups −/+ and +/+ (
β
= 0.04;
p
= 0.03 and
β
= 0.06;
p
< 0.01, respectively) in comparison to the −/− reference group. Low concentrations of HDL-c were directly and significantly associated with increased T2D risk (
β
= −0.70;
p
< 0.01). WHtR, male gender, age, and insulin resistance were also associated with T2D risk (
p
< 0.05). There was no significant direct effect for any of the
ABCA1
groups on T2D risk:
p
= 0.99,
p
= 0.58, and
p
= 0.91 for groups +/–, −/+, and +/+ respectively.
Conclusions
The
ABCA1
rs9282541 (R230C) allele is associated with T2D in Mexicans through its effect on lowering HDL-c levels. This is the first report demonstrating that HDL-c levels act as an intermediate factor between an
ABCA1
variant and T2D.</description><subject>ABCA1 protein</subject><subject>Adult</subject><subject>Alleles</subject><subject>ATP Binding Cassette Transporter 1 - genetics</subject><subject>ATP-binding protein</subject><subject>Biomarkers - analysis</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Single-nucleotide polymorphism</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEoqXwAhzQSFy4hI7txPEelxQoUhESKmfLSSa7rrL2YjstvXGEKyeer0-Cly1_xIHTzMi_75uRv6J4zPA5Q2yOY4WSqRI5lsiYakp1pzhkTR6VUPLuX_1B8SDGC0TRCNXcLw4ERyYXTB4W399zgS10cwLnE9x8-Xbz-Wst6_b4HC5NsMYl8COkNcHyRbtksCJHYCOYGH1vTaIBrmxaQ7reEnAYrOkoUQTr4C19sr1xMauDn1drMA5oHKnPlg4mf0XBuhWcnpyV_dpPFBMFP8FElzTFh8W90UyRHt3Wo-LDq5fn7Wl59u71m3aZJaKpU2lqsxhr0StOWDNOg6oXPaqhz03FRzmMVDedMp3qGmxkx1hVMYl1fhhISSmOimd7323wH-d8g97Y2NM0GUd-jpqLGhcokKuMPv0HvfBzcPk6zSteMc5Q7ii-p_rgYww06m2wGxOuNUO9y03vc9M5N_0zN70TPbm1nrsNDb8lv4LKgNgDcbv7NAp_dv_H9gcI5aMD</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Ochoa-Guzmán, A.</creator><creator>Moreno-Macías, H.</creator><creator>Guillén-Quintero, D.</creator><creator>Chávez-Talavera, O.</creator><creator>Ordoñez-Sánchez, M. L.</creator><creator>Segura-Kato, Y.</creator><creator>Ortíz, V.</creator><creator>Díaz-Díaz, E.</creator><creator>Muñoz-Hernández, L.</creator><creator>García, A.</creator><creator>Pérez-Méndez, O.</creator><creator>Zentella-Dehesa, A.</creator><creator>Aguilar-Salinas, C. A.</creator><creator>Tusié-Luna, M. T.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4478-038X</orcidid></search><sort><creationdate>20200801</creationdate><title>R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels</title><author>Ochoa-Guzmán, A. ; Moreno-Macías, H. ; Guillén-Quintero, D. ; Chávez-Talavera, O. ; Ordoñez-Sánchez, M. L. ; Segura-Kato, Y. ; Ortíz, V. ; Díaz-Díaz, E. ; Muñoz-Hernández, L. ; García, A. ; Pérez-Méndez, O. ; Zentella-Dehesa, A. ; Aguilar-Salinas, C. A. ; Tusié-Luna, M. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a5a9f53c82e0512ed859c08dcd8542f6dfe57b8ab8b7076b114416056dfde8663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ABCA1 protein</topic><topic>Adult</topic><topic>Alleles</topic><topic>ATP Binding Cassette Transporter 1 - genetics</topic><topic>ATP-binding protein</topic><topic>Biomarkers - analysis</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ochoa-Guzmán, A.</creatorcontrib><creatorcontrib>Moreno-Macías, H.</creatorcontrib><creatorcontrib>Guillén-Quintero, D.</creatorcontrib><creatorcontrib>Chávez-Talavera, O.</creatorcontrib><creatorcontrib>Ordoñez-Sánchez, M. L.</creatorcontrib><creatorcontrib>Segura-Kato, Y.</creatorcontrib><creatorcontrib>Ortíz, V.</creatorcontrib><creatorcontrib>Díaz-Díaz, E.</creatorcontrib><creatorcontrib>Muñoz-Hernández, L.</creatorcontrib><creatorcontrib>García, A.</creatorcontrib><creatorcontrib>Pérez-Méndez, O.</creatorcontrib><creatorcontrib>Zentella-Dehesa, A.</creatorcontrib><creatorcontrib>Aguilar-Salinas, C. A.</creatorcontrib><creatorcontrib>Tusié-Luna, M. T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ochoa-Guzmán, A.</au><au>Moreno-Macías, H.</au><au>Guillén-Quintero, D.</au><au>Chávez-Talavera, O.</au><au>Ordoñez-Sánchez, M. L.</au><au>Segura-Kato, Y.</au><au>Ortíz, V.</au><au>Díaz-Díaz, E.</au><au>Muñoz-Hernández, L.</au><au>García, A.</au><au>Pérez-Méndez, O.</au><au>Zentella-Dehesa, A.</au><au>Aguilar-Salinas, C. A.</au><au>Tusié-Luna, M. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>43</volume><issue>8</issue><spage>1061</spage><epage>1071</epage><pages>1061-1071</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders.
ABCA1
variants have been shown to be associated to these conditions. We sought to test the combined effect of two
ABCA1
gene common variants, rs2422493 (− 565C > T) and rs9282541 (R230C) on HDL-c levels and T2D risk.
Methods
Path analysis was conducted in 3,303 Mexican-mestizos to assess the specific contributions of rs2422493 and rs9282541
ABCA1
variants, insulin resistance, waist-to-height ratio (WHtR), and age on HDL-c levels and T2D risk. Participants were classified into four groups according to their
ABCA1
variants carrier status: (i) the reference group carried wild type alleles for both
ABCA1
variants (−/−), (ii) +/– were carriers of rs2422493 but non-carriers of rs9282541, (iii) −/+ for carriers of rs9282541 but not carriers of rs2422493 and (iv) carriers of minor alleles for both SNPs (+/+). Principal components from two previous genome-wide association studies were used to control for ethnicity.
Results
We identified significant indirect effects on T2D risk mediated by HDL-c in groups −/+ and +/+ (
β
= 0.04;
p
= 0.03 and
β
= 0.06;
p
< 0.01, respectively) in comparison to the −/− reference group. Low concentrations of HDL-c were directly and significantly associated with increased T2D risk (
β
= −0.70;
p
< 0.01). WHtR, male gender, age, and insulin resistance were also associated with T2D risk (
p
< 0.05). There was no significant direct effect for any of the
ABCA1
groups on T2D risk:
p
= 0.99,
p
= 0.58, and
p
= 0.91 for groups +/–, −/+, and +/+ respectively.
Conclusions
The
ABCA1
rs9282541 (R230C) allele is associated with T2D in Mexicans through its effect on lowering HDL-c levels. This is the first report demonstrating that HDL-c levels act as an intermediate factor between an
ABCA1
variant and T2D.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32016916</pmid><doi>10.1007/s40618-020-01187-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4478-038X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8386 |
| ispartof | Journal of endocrinological investigation, 2020-08, Vol.43 (8), p.1061-1071 |
| issn | 1720-8386 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2350903028 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | ABCA1 protein Adult Alleles ATP Binding Cassette Transporter 1 - genetics ATP-binding protein Biomarkers - analysis Cholesterol Cholesterol, HDL - blood Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Endocrinology Female Follow-Up Studies Genetic Predisposition to Disease Genome-Wide Association Study Genomes High density lipoprotein Humans Insulin Insulin resistance Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Mexico - epidemiology Middle Aged Original Article Polymorphism, Single Nucleotide Prognosis Single-nucleotide polymorphism |
| title | R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels |
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