Lessons Learned From Multi-regional Trials With Signals of Treatment Effect Heterogeneity

Inconsistent results across regions have been reported in a number of recent large trials. In this research, by reviewing results from studies that showed inconsistent treatment effects, and summarizing lessons learned, we provide some recommendations for minimizing the chance of inconsistency and a...

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Veröffentlicht in:	Therapeutic innovation & regulatory science 2020, Vol.54 (1), p.21-31
Hauptverfasser:	Li, Gang, Quan, Hui, Lan, Gordon, Ouyang, Soo Peter, Chen, Fei, Robieson, Weining, Wang, William, Binkowitz, Bruce, Yuan, Shuai Sammy, Tanaka, Yoko, Chen, Josh, Matsuoka, Nobushige, Zhang, Lanju, Yang, Song, Gallo, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical Research - standards Clinical trials Clinical Trials as Topic Drug Safety and Pharmacovigilance Heterogeneity Humans Medicine Pharmacotherapy Pharmacy Regions Research Design - standards Review
Online-Zugang:	Volltext
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