The elevated risk of ovarian clear cell carcinoma among Asian Pacific Islander women in the United States is not affected by birthplace

The elevated risk of ovarian clear cell carcinoma among Asian Pacific Islander women in the United States is not affected by birthplace

To determine incidence of ovarian clear cell cancer (OCCC) by race ethnicity and how that relationship is affected by birthplace among Asian Pacific Islanders (API). The 18 registries of the U.S. Surveillance, Epidemiology, and End Results (SEER) dataset were queried to identify all women registered...

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Veröffentlicht in:Gynecologic oncology 2020-04, Vol.157 (1), p.62-66
Hauptverfasser: Korenaga, Travis-Riley, Ward, Kristy K., Saenz, Cheryl, McHale, Michael T., Plaxe, Steven
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container_end_page 66
container_issue 1
container_start_page 62
container_title Gynecologic oncology
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creator Korenaga, Travis-Riley
Ward, Kristy K.
Saenz, Cheryl
McHale, Michael T.
Plaxe, Steven
description To determine incidence of ovarian clear cell cancer (OCCC) by race ethnicity and how that relationship is affected by birthplace among Asian Pacific Islanders (API). The 18 registries of the U.S. Surveillance, Epidemiology, and End Results (SEER) dataset were queried to identify all women registered with epithelial ovarian cancer from 1973 to 2013. Relative risks of OCCC to non-OCCC based on ethnicity and birthplace were compared. We identified 72, 501 women with epithelial ovarian cancer in the dataset; of these, 5078 (7.0%) had OCCC and 4859 (6.7%) were API. The age-adjusted incidence rate/100,000 women of OCCC was significantly higher in API women (0.6, 0.5–0.6 95% CI) compared to any other ethnicity. A significantly higher proportion of API women had OCCC (14.5%) compared to their White (6.6%, RR 2.2, p 
doi_str_mv 10.1016/j.ygyno.2020.01.034
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The 18 registries of the U.S. Surveillance, Epidemiology, and End Results (SEER) dataset were queried to identify all women registered with epithelial ovarian cancer from 1973 to 2013. Relative risks of OCCC to non-OCCC based on ethnicity and birthplace were compared. We identified 72, 501 women with epithelial ovarian cancer in the dataset; of these, 5078 (7.0%) had OCCC and 4859 (6.7%) were API. The age-adjusted incidence rate/100,000 women of OCCC was significantly higher in API women (0.6, 0.5–0.6 95% CI) compared to any other ethnicity. A significantly higher proportion of API women had OCCC (14.5%) compared to their White (6.6%, RR 2.2, p &lt; 0.0001) and Black counterparts (4.3%, RR 3.4, p &lt; 0.0001). The majority of API women were foreign-born (70.8%). The relative risk of clear cell compared to non-clear cell epithelial ovarian cancer was not demonstrably different among foreign born API women with ovarian cancer (RR 1.1, 95% CI 0.9 to 1.3, p = 0.6). We have demonstrated that, in the US, there is an elevated risk of OCCC associated with API ethnicity. Place of birth does not appear to significantly modify the association, suggesting that the increased risk of OCCC in API women may not be affected by acculturation or environmental exposure. Future research exploring the complex relationships between ethnicity and risk of malignancy will be important as we make progress in understanding disease process and treatment. •In the US, there is an elevated risk of ovarian clear cell carcinoma associated with Asian/Pacific Islander ethnicity.•Proportion of ovarian clear cell carcinoma was significantly higher in Asian/Pacific Islander women than other ethnicities.•Birthplace does not significantly modify the association between ethnicity and incidence of ovarian clear cell carcinoma.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2020.01.034</identifier><identifier>PMID: 32008796</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Gynecologic oncology, 2020-04, Vol.157 (1), p.62-66</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. 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The 18 registries of the U.S. Surveillance, Epidemiology, and End Results (SEER) dataset were queried to identify all women registered with epithelial ovarian cancer from 1973 to 2013. Relative risks of OCCC to non-OCCC based on ethnicity and birthplace were compared. We identified 72, 501 women with epithelial ovarian cancer in the dataset; of these, 5078 (7.0%) had OCCC and 4859 (6.7%) were API. The age-adjusted incidence rate/100,000 women of OCCC was significantly higher in API women (0.6, 0.5–0.6 95% CI) compared to any other ethnicity. A significantly higher proportion of API women had OCCC (14.5%) compared to their White (6.6%, RR 2.2, p &lt; 0.0001) and Black counterparts (4.3%, RR 3.4, p &lt; 0.0001). The majority of API women were foreign-born (70.8%). The relative risk of clear cell compared to non-clear cell epithelial ovarian cancer was not demonstrably different among foreign born API women with ovarian cancer (RR 1.1, 95% CI 0.9 to 1.3, p = 0.6). We have demonstrated that, in the US, there is an elevated risk of OCCC associated with API ethnicity. Place of birth does not appear to significantly modify the association, suggesting that the increased risk of OCCC in API women may not be affected by acculturation or environmental exposure. Future research exploring the complex relationships between ethnicity and risk of malignancy will be important as we make progress in understanding disease process and treatment. •In the US, there is an elevated risk of ovarian clear cell carcinoma associated with Asian/Pacific Islander ethnicity.•Proportion of ovarian clear cell carcinoma was significantly higher in Asian/Pacific Islander women than other ethnicities.•Birthplace does not significantly modify the association between ethnicity and incidence of ovarian clear cell carcinoma.</description><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9r3DAQxUVpabZJPkGh6NiL3ZFke61DDyH0TyDQQpOzkKVRoq0tbSXvlv0E_dqRs0mPOQ0Mv_eGeY-Q9wxqBqz7tKkPd4cQaw4camA1iOYVWTGQbdX1rXxNVgASqp63_Ql5l_MGAAQw_pacCA7Qr2W3Iv9u7pHiiHs9o6XJ5980Ohr3OnkdqBlRJ2pwHKnRyfgQJ031FMMdvcgL8FMb77yhV3nUwWKif-OEgfpA5-J7G_zi-msu5pn6TEOcqXYOzbIeDnTwab7fjtrgGXnj9Jjx_GmektuvX24uv1fXP75dXV5cV0a0cq4kaj4IjQNfO6NtIxzvh1ZK6ThrhoZZDlpaYAY7y3DdIG_MMFjbYm97Z6Q4JR-PvtsU_-wwz2ryeXlQB4y7rLhoS45dL0VBxRE1Keac0Klt8pNOB8VALQ2ojXpsQC0NKGCqKIvqw9OB3TCh_a95jrwAn48Aljf3HpPKxmMwaH0qwSgb_YsHHgAOg5sA</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Korenaga, Travis-Riley</creator><creator>Ward, Kristy K.</creator><creator>Saenz, Cheryl</creator><creator>McHale, Michael T.</creator><creator>Plaxe, Steven</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>The elevated risk of ovarian clear cell carcinoma among Asian Pacific Islander women in the United States is not affected by birthplace</title><author>Korenaga, Travis-Riley ; Ward, Kristy K. ; Saenz, Cheryl ; McHale, Michael T. ; Plaxe, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-9ea2b3aeb27fcad43f28b5999f214b41d20a9d01ce6d1e74e24cbbdd5e8d8fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korenaga, Travis-Riley</creatorcontrib><creatorcontrib>Ward, Kristy K.</creatorcontrib><creatorcontrib>Saenz, Cheryl</creatorcontrib><creatorcontrib>McHale, Michael T.</creatorcontrib><creatorcontrib>Plaxe, Steven</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korenaga, Travis-Riley</au><au>Ward, Kristy K.</au><au>Saenz, Cheryl</au><au>McHale, Michael T.</au><au>Plaxe, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The elevated risk of ovarian clear cell carcinoma among Asian Pacific Islander women in the United States is not affected by birthplace</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2020-04</date><risdate>2020</risdate><volume>157</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>To determine incidence of ovarian clear cell cancer (OCCC) by race ethnicity and how that relationship is affected by birthplace among Asian Pacific Islanders (API). The 18 registries of the U.S. Surveillance, Epidemiology, and End Results (SEER) dataset were queried to identify all women registered with epithelial ovarian cancer from 1973 to 2013. Relative risks of OCCC to non-OCCC based on ethnicity and birthplace were compared. We identified 72, 501 women with epithelial ovarian cancer in the dataset; of these, 5078 (7.0%) had OCCC and 4859 (6.7%) were API. The age-adjusted incidence rate/100,000 women of OCCC was significantly higher in API women (0.6, 0.5–0.6 95% CI) compared to any other ethnicity. A significantly higher proportion of API women had OCCC (14.5%) compared to their White (6.6%, RR 2.2, p &lt; 0.0001) and Black counterparts (4.3%, RR 3.4, p &lt; 0.0001). The majority of API women were foreign-born (70.8%). The relative risk of clear cell compared to non-clear cell epithelial ovarian cancer was not demonstrably different among foreign born API women with ovarian cancer (RR 1.1, 95% CI 0.9 to 1.3, p = 0.6). We have demonstrated that, in the US, there is an elevated risk of OCCC associated with API ethnicity. Place of birth does not appear to significantly modify the association, suggesting that the increased risk of OCCC in API women may not be affected by acculturation or environmental exposure. Future research exploring the complex relationships between ethnicity and risk of malignancy will be important as we make progress in understanding disease process and treatment. •In the US, there is an elevated risk of ovarian clear cell carcinoma associated with Asian/Pacific Islander ethnicity.•Proportion of ovarian clear cell carcinoma was significantly higher in Asian/Pacific Islander women than other ethnicities.•Birthplace does not significantly modify the association between ethnicity and incidence of ovarian clear cell carcinoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32008796</pmid><doi>10.1016/j.ygyno.2020.01.034</doi><tpages>5</tpages></addata></record>
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