Antidepressants induce profibrotic responses via the lysophosphatidic acid receptor LPA1

Preclinical and clinical studies have indicated that antidepressants can promote inflammation and fibrogenesis, particularly in the lung, by mechanisms not fully elucidated. We have previously shown that different classes of antidepressants can activate the lysophosphatidic acid (LPA) receptor LPA1,...

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Veröffentlicht in:	European journal of pharmacology 2020-04, Vol.873, p.172963-172963, Article 172963
Hauptverfasser:	Olianas, Maria C., Dedoni, Simona, Onali, Pierluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Human fibroblasts LPA1 receptor Mitogenesis Transforming growth factor-β1 α-smooth muscle actin
Online-Zugang:	Volltext
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