Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities

•Two new prenylflavonoids, morachlcone D and E, were identified from mulberry leaf.•Morachlcone D could inhibit oxidative damage in HT22 cells.•The mechanisms of morachlcone D against oxidative damage were revealed. Mulberry leaf is a vegetable used in daily diet. It can bring delicious taste and mu...

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Veröffentlicht in:	Food chemistry 2020-06, Vol.315, p.126236-126236, Article 126236
Hauptverfasser:	Wen, Lingrong, Shi, Dingding, Zhou, Ting, Tu, Jiaming, He, Mingyang, Jiang, Yueming, Yang, Bao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant activity Bioactivity Cell Death - drug effects Cell Line Ferroptosis - drug effects Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Gene Expression Regulation - drug effects Glutamic Acid - toxicity Hippocampus - cytology Hippocampus - metabolism Iron - metabolism Mice Molecular Structure Morus - chemistry Morus alba Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology NMR Piperazines - toxicity Plant Leaves - chemistry Prenylated flavonoid Reactive Oxygen Species - metabolism
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