Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies

[Display omitted] Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation. The structure and substitution degrees of these derivatives were confirmed by 1H NMR- and FTIR-spectroscopy. These derivatives are more hydrophobi...

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Veröffentlicht in:	International journal of pharmaceutics 2020-03, Vol.577, p.119093-119093, Article 119093
Hauptverfasser:	Agibayeva, Laura E., Kaldybekov, Daulet B., Porfiryeva, Natalia N., Garipova, Venera R., Mangazbayeva, Rauash A., Moustafine, Rouslan I., Semina, Irina I., Mun, Grigoriy A., Kudaibergenov, Sarkyt E., Khutoryanskiy, Vitaliy V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gellan gum Glaucoma In situ gelling Methacrylation Mucoadhesion Ocular drug delivery Pilocarpine Wash out50
Online-Zugang:	Volltext
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