Physicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods
The influences of different extraction methods on the yields, physicochemical properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides...
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| Veröffentlicht in: | International journal of biological macromolecules 2020-05, Vol.150, p.114-121 |
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| creator | Li, Jian Niu, Debao Zhang, Ying Zeng, Xin-An |
| description | The influences of different extraction methods on the yields, physicochemical properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides (NP), which include hot water extraction (HWE), pulsed electric field-assisted extraction (PEFAE) and ultrasonic-assisted extraction (UAE). The extraction yields, sugar contents, uronic acid contents, molecular weights, monosaccharide proportions, antioxidant activities and antiproliferative abilities of three NP samples were significantly different. However, their preliminary structural characteristics and monosaccharide types were similar. More specifically, UAE-NP had the highest extraction yield, the smallest molecular weight and the best antioxidant activities. Especially, UAE-NP showed excellent antiproliferative abilities. Compared with HWE-NP and PEFAE-NP, the IC50 value of UAE-NP on HepG2 cells reduced by 45.45% and 33.14%, respectively. The highest antioxidant activities of the UAE-NP might be attributed to its smaller molecular weight, lower Gal content and higher Fuc content. The strongest antiproliferative effects of the UAE-NP might be related to the low molecular weight. Overall, UAE could be a potential technique for the extraction of high-quality NP due to its high yield, high efficiency and notable bioactivities. |
| doi_str_mv | 10.1016/j.ijbiomac.2019.12.157 |
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(Noni) based on different extraction methods</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Li, Jian ; Niu, Debao ; Zhang, Ying ; Zeng, Xin-An</creator><creatorcontrib>Li, Jian ; Niu, Debao ; Zhang, Ying ; Zeng, Xin-An</creatorcontrib><description>The influences of different extraction methods on the yields, physicochemical properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides (NP), which include hot water extraction (HWE), pulsed electric field-assisted extraction (PEFAE) and ultrasonic-assisted extraction (UAE). The extraction yields, sugar contents, uronic acid contents, molecular weights, monosaccharide proportions, antioxidant activities and antiproliferative abilities of three NP samples were significantly different. However, their preliminary structural characteristics and monosaccharide types were similar. More specifically, UAE-NP had the highest extraction yield, the smallest molecular weight and the best antioxidant activities. Especially, UAE-NP showed excellent antiproliferative abilities. Compared with HWE-NP and PEFAE-NP, the IC50 value of UAE-NP on HepG2 cells reduced by 45.45% and 33.14%, respectively. The highest antioxidant activities of the UAE-NP might be attributed to its smaller molecular weight, lower Gal content and higher Fuc content. The strongest antiproliferative effects of the UAE-NP might be related to the low molecular weight. Overall, UAE could be a potential technique for the extraction of high-quality NP due to its high yield, high efficiency and notable bioactivities.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2019.12.157</identifier><identifier>PMID: 32006573</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antioxidant activity ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Antiproliferative ability ; Chemical Fractionation - methods ; Chemical Phenomena ; Different extraction methods ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - pharmacology ; Molecular Weight ; Monosaccharides - chemistry ; Morinda - chemistry ; Noni polysaccharide ; Physicochemical properties ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; Spectrum Analysis</subject><ispartof>International journal of biological macromolecules, 2020-05, Vol.150, p.114-121</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-90f06aee525b319232a0bc081db54276d10039badd70be3a6fbb9422cbc6e71a3</citedby><cites>FETCH-LOGICAL-c368t-90f06aee525b319232a0bc081db54276d10039badd70be3a6fbb9422cbc6e71a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813019392049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32006573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Niu, Debao</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zeng, Xin-An</creatorcontrib><title>Physicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>The influences of different extraction methods on the yields, physicochemical properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides (NP), which include hot water extraction (HWE), pulsed electric field-assisted extraction (PEFAE) and ultrasonic-assisted extraction (UAE). The extraction yields, sugar contents, uronic acid contents, molecular weights, monosaccharide proportions, antioxidant activities and antiproliferative abilities of three NP samples were significantly different. However, their preliminary structural characteristics and monosaccharide types were similar. More specifically, UAE-NP had the highest extraction yield, the smallest molecular weight and the best antioxidant activities. Especially, UAE-NP showed excellent antiproliferative abilities. Compared with HWE-NP and PEFAE-NP, the IC50 value of UAE-NP on HepG2 cells reduced by 45.45% and 33.14%, respectively. The highest antioxidant activities of the UAE-NP might be attributed to its smaller molecular weight, lower Gal content and higher Fuc content. The strongest antiproliferative effects of the UAE-NP might be related to the low molecular weight. Overall, UAE could be a potential technique for the extraction of high-quality NP due to its high yield, high efficiency and notable bioactivities.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidant activity</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Antiproliferative ability</subject><subject>Chemical Fractionation - methods</subject><subject>Chemical Phenomena</subject><subject>Different extraction methods</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Molecular Weight</subject><subject>Monosaccharides - chemistry</subject><subject>Morinda - chemistry</subject><subject>Noni polysaccharide</subject><subject>Physicochemical properties</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Spectrum Analysis</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuFDEQtBCILIFfiHwMEjPxY8czcwNF4SEtCQc4W370aHs1M15sb5T9nvwoHjbhyqna7apqdRchF5zVnHF1tatxZzFMxtWC8b7mouZN-4KseNf2FWNMviQrxte86rhkZ-RNSrvSVQ3vXpMzKZaylSvy-GN7TOiC28KEzox0H8MeYkZIH6iZM4YH9AVL7f--y_-IA0ST8R6ocQVwYdMw0H0Yj8k4tzURfWkNMUz0e4g4e0Md5ohDERu6qenlbZjxPbUmgadhph6HYgplEDzkuNiW5gR5G3x6S14NZkzw7gnPya_PNz-vv1abuy_frj9tKidVl6ueDUwZgEY0VvJeSGGYdazj3jZr0SrPy1V6a7xvmQVp1GBtvxbCWaeg5Uaek8uTb9nx9wFS1hMmB-NoZgiHpIVsGOsbxdpCVSeqiyGlCIPeR5xMPGrO9BKQ3unngPQSkOZCl4CK8OJpxsFO4P_JnhMphI8nApRN7xGiTg5hduAxgsvaB_zfjD-8A6m8</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Li, Jian</creator><creator>Niu, Debao</creator><creator>Zhang, Ying</creator><creator>Zeng, Xin-An</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>Physicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods</title><author>Li, Jian ; Niu, Debao ; Zhang, Ying ; Zeng, Xin-An</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-90f06aee525b319232a0bc081db54276d10039badd70be3a6fbb9422cbc6e71a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidant activity</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Antiproliferative ability</topic><topic>Chemical Fractionation - methods</topic><topic>Chemical Phenomena</topic><topic>Different extraction methods</topic><topic>Free Radical Scavengers - chemistry</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Molecular Weight</topic><topic>Monosaccharides - chemistry</topic><topic>Morinda - chemistry</topic><topic>Noni polysaccharide</topic><topic>Physicochemical properties</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Spectrum Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Niu, Debao</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zeng, Xin-An</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jian</au><au>Niu, Debao</au><au>Zhang, Ying</au><au>Zeng, Xin-An</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>150</volume><spage>114</spage><epage>121</epage><pages>114-121</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>The influences of different extraction methods on the yields, physicochemical properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides (NP), which include hot water extraction (HWE), pulsed electric field-assisted extraction (PEFAE) and ultrasonic-assisted extraction (UAE). The extraction yields, sugar contents, uronic acid contents, molecular weights, monosaccharide proportions, antioxidant activities and antiproliferative abilities of three NP samples were significantly different. However, their preliminary structural characteristics and monosaccharide types were similar. More specifically, UAE-NP had the highest extraction yield, the smallest molecular weight and the best antioxidant activities. Especially, UAE-NP showed excellent antiproliferative abilities. Compared with HWE-NP and PEFAE-NP, the IC50 value of UAE-NP on HepG2 cells reduced by 45.45% and 33.14%, respectively. The highest antioxidant activities of the UAE-NP might be attributed to its smaller molecular weight, lower Gal content and higher Fuc content. The strongest antiproliferative effects of the UAE-NP might be related to the low molecular weight. Overall, UAE could be a potential technique for the extraction of high-quality NP due to its high yield, high efficiency and notable bioactivities.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32006573</pmid><doi>10.1016/j.ijbiomac.2019.12.157</doi><tpages>8</tpages></addata></record> |
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| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidant activity Antioxidants - chemistry Antioxidants - pharmacology Antiproliferative ability Chemical Fractionation - methods Chemical Phenomena Different extraction methods Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Molecular Weight Monosaccharides - chemistry Morinda - chemistry Noni polysaccharide Physicochemical properties Plant Extracts - chemistry Plant Extracts - pharmacology Polysaccharides - chemistry Polysaccharides - pharmacology Spectrum Analysis |
| title | Physicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods |
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