AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics

Mitochondrial fusion and fission dynamics fine-tune cellular calcium homeostasis, ATP production capacity and ROS production and play important roles in cell proliferation and migration. Dysregulated mitochondrial dynamics is closely related to tumor development, but the mechanism of mitochondrial d...

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Veröffentlicht in:	Oncogene 2020-03, Vol.39 (13), p.2707-2723
Hauptverfasser:	Qi, Miao, Dai, Dan, Liu, Jin, Li, Zhongqi, Liang, Panpan, Wang, Yue, Cheng, Lu, Zhan, Yihong, An, Zhifeng, Song, Yaoyao, Yang, Yana, Yan, Xiaohui, Xiao, Hui, Shao, Huanjie
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/106 13/51 13/89 14/105 14/19 14/28 38/77 631/67/1612/1350 631/80/642/333 631/80/86/2368 64/60 Animals Apoptosis Calcium homeostasis Calcium signalling Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell Biology Cell fusion Cell growth Cell Line, Tumor Cell migration Cell Proliferation Datasets as Topic Development and progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects GTP Phosphohydrolases - metabolism Health aspects Homeostasis Human Genetics Humans Inflammasomes Internal Medicine Kaplan-Meier Estimate Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology MAP kinase MAP Kinase Signaling System - genetics Medicine Medicine & Public Health Melanoma Mice Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial Dynamics - genetics Mitochondrial Proteins - metabolism Non-small cell lung carcinoma Oncology Production capacity Prognosis Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Small Interfering - metabolism Signal transduction Small cell lung carcinoma Tumor proteins Up-Regulation Xenograft Model Antitumor Assays
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