YY1‐PVT1 affects trophoblast invasion and adhesion by regulating mTOR pathway‐mediated autophagy

Insufficient trophoblast invasion is the key factor for the occurrence of recurrent spontaneous abortions (RSA). Our previous studies identified Yin Yang 1 (YY1) as a transcription factor involved in the regulation of trophoblast invasiveness at the maternal–fetal interface. Long noncoding RNAs (lnc...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.6637-6646
Hauptverfasser:	Yang, Dongyong, Ding, Jinli, Wang, Yanqing, Yuan, Mengqin, Xian, Shu, Zhang, Li, Liu, Shiyi, Dai, Fangfang, Wang, Feiyan, Zheng, Yajing, Zhao, Xin, Liao, Shujie, Cheng, Yanxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - genetics Adhesion Adult Apoptosis Apoptosis - genetics Autophagy Autophagy - genetics Autophagy - physiology Binding sites Cell Adhesion - genetics Cell Adhesion - physiology Cell Line Cell Movement - genetics Chromatin Electrophoretic mobility Female Fetuses Gene expression Gene Expression Regulation - genetics Humans Immunoprecipitation invasion Invasiveness mTOR Pathogenesis Phagocytosis Placenta Plasmacytoma Pregnancy Promoter Regions, Genetic - genetics PVT1 recurrent spontaneous abortion RNA, Long Noncoding - genetics Signal Transduction - physiology TOR protein TOR Serine-Threonine Kinases - genetics Transcription, Genetic - genetics Translocation trophoblast Trophoblasts Trophoblasts - physiology Young Adult YY1 protein YY1 Transcription Factor - genetics
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