Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affinities between pro- and anti-apoptotic proteins dete...

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Veröffentlicht in:	Molecular cell 2020-02, Vol.77 (4), p.901-912.e9
Hauptverfasser:	Bogner, Christian, Kale, Justin, Pogmore, Justin, Chi, Xiaoke, Shamas-Din, Aisha, Fradin, Cécile, Leber, Brian, Andrews, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric activation apoptosis Bad Bax Bcl-2 family Bcl-xL complexes Bid mitochondria MOMP switch-like activation
Online-Zugang:	Volltext
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