Substrate‐dependent transport mechanism in AcrB of multidrug resistant bacteria

The multidrug resistance (MDR) system effectively expels antibiotics out of bacteria causing serious issues during bacterial infection. In addition to drug, indole, a common metabolic waste of bacteria, is expelled by MDR system of gram‐negative bacteria for their survival. Experimental results sugg...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2020-07, Vol.88 (7), p.853-864
Hauptverfasser:	Jewel, Yead, Van Dinh, Quyen, Liu, Jin, Dutta, Prashanta
Format:	Artikel
Sprache:	eng
Schlagworte:	AcrB AcrB protein Anti-Bacterial Agents - pharmacology Antibiotics Aspartic acid Aspartic Acid - chemistry Aspartic Acid - metabolism Bacteria Bacterial diseases Binding Sites Biological Transport coarsegrained molecular simulation Computer simulation Crystallography, X-Ray Domains Drug resistance Drug Resistance, Multiple, Bacterial - genetics Efflux Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Extrusion Gram-negative bacteria indole Indoles Indoles - chemistry Indoles - metabolism Metabolic wastes Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Monomers Multidrug resistance Multidrug Resistance-Associated Proteins - chemistry Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism multidrug resistant bacteria Multidrug resistant organisms Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protonation Protons Pumping Residues Substrate Specificity Substrates Thermodynamics
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