Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly

There is a real need for new antibiotics against self‐evolving bacteria. One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimi...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-02, Vol.16 (8), p.e1907309-n/a
Hauptverfasser: Song, Jingwen, Yuan, Chengqian, Jiao, Tifeng, Xing, Ruirui, Yang, Mengyao, Adams, Dave J., Yan, Xuehai
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container_start_page e1907309
container_title Small (Weinheim an der Bergstrasse, Germany)
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creator Song, Jingwen
Yuan, Chengqian
Jiao, Tifeng
Xing, Ruirui
Yang, Mengyao
Adams, Dave J.
Yan, Xuehai
description There is a real need for new antibiotics against self‐evolving bacteria. One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimicrobial biometallohydrogels based on the self‐assembly and local mineralization of Ag+‐coordinated Fmoc‐amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications. Broad‐spectrum antimicrobial biometallohydrogels based on Ag+‐coordinated Fmoc‐amino acids self‐assembly and local mineralization are presented. These biometallohydrogels have the advantages of reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. This study provides insights into the design and development of a multifunctional integration platform based on biomolecules coordinated self‐assembly toward a broad range of biomedical applications.
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One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimicrobial biometallohydrogels based on the self‐assembly and local mineralization of Ag+‐coordinated Fmoc‐amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications. Broad‐spectrum antimicrobial biometallohydrogels based on Ag+‐coordinated Fmoc‐amino acids self‐assembly and local mineralization are presented. These biometallohydrogels have the advantages of reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. 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This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications. Broad‐spectrum antimicrobial biometallohydrogels based on Ag+‐coordinated Fmoc‐amino acids self‐assembly and local mineralization are presented. These biometallohydrogels have the advantages of reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. This study provides insights into the design and development of a multifunctional integration platform based on biomolecules coordinated self‐assembly toward a broad range of biomedical applications.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31994844</pmid><doi>10.1002/smll.201907309</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0890-0340</orcidid><oa>free_for_read</oa></addata></record>
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subjects Amino acids
Amino Acids - chemistry
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
antimicrobial
Assembly
Bacteria
Bioavailability
Biocompatibility
Biomedical materials
biometallohydrogels
Biomolecules
broad‐spectrum
Cell death
coordinated self‐assembly
Cytoplasm
Drug delivery systems
E coli
Escherichia coli - drug effects
Female
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Membranes
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Nanotechnology
NIH 3T3 Cells
Silver - chemistry
Silver - pharmacology
Staphylococcus aureus - drug effects
Sustained release
Toxicity
Trace Elements - chemistry
Trace Elements - pharmacology
title Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly
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