High serum substance P levels and mortality after malignant middle cerebral artery infarction
Previously our team found higher serum substance P concentrations at day 1 of a malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving patients. Thus, the objective of this study was to determine whether serum substance P levels during the first week of MMCAI could pr...
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| Veröffentlicht in: | Journal of critical care 2020-06, Vol.57, p.1-4 |
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| creator | Lorente, Leonardo Martín, María M. Pérez-Cejas, Antonia González-Rivero, Agustín F. Argueso, Mónica Ramos, Luis Solé-Violán, Jordi Cáceres, Juan J. Jiménez, Alejandro García-Marín, Victor |
| description | Previously our team found higher serum substance P concentrations at day 1 of a malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving patients. Thus, the objective of this study was to determine whether serum substance P levels during the first week of MMCAI could predict mortality.
We included patients with MMCAI defined as computed tomography findings of acute infarction in at least of 50% of the territory and Glasgow Coma Scale ≤8. We determined serum concentrations of substance P on days 1, 4 and 8 of MMCAI. Thirty-day mortality was the study end-point.
Serum substance P concentrations at days 1 (p |
| doi_str_mv | 10.1016/j.jcrc.2020.01.022 |
| format | Article |
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We included patients with MMCAI defined as computed tomography findings of acute infarction in at least of 50% of the territory and Glasgow Coma Scale ≤8. We determined serum concentrations of substance P on days 1, 4 and 8 of MMCAI. Thirty-day mortality was the study end-point.
Serum substance P concentrations at days 1 (p < .001), 4 (p < .001), and 8 (p = .001) of MMCAI in non-surviving (n = 34) were higher than in surviving patients (n = 34). Receiver operating characteristic analyses showed that serum substance P concentrations at days 1, 4, and 8 of MMCAI had an area under curve (95% confidence intervals) to predict 30-day mortality of 0.77 (0.66–0.87; p < .001), 0.82 (0.69–0.91; p < .001) and 0.85 (0.72–0.94; p < .001) respectively.
The two new findings of our study are that non-surviving MMCAI patients showed higher serum substance P levels at day 1, 4 and 8 than surviving, and that those levels could predict 30-day mortality.
•Serum substance P levels during the first week of a cerebral infarction were higher in non-surviving patients.•Serum substance Plevels during the first week of a cerebral infarctioncould predict early mortality.</description><identifier>ISSN: 0883-9441</identifier><identifier>EISSN: 1557-8615</identifier><identifier>DOI: 10.1016/j.jcrc.2020.01.022</identifier><identifier>PMID: 31991332</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Blood platelets ; Brain damage ; Chronic obstructive pulmonary disease ; Critical care ; Cytokines ; Edema ; Female ; Glasgow Coma Scale ; Humans ; Hypertension ; Infarction, Middle Cerebral Artery - blood ; Infarction, Middle Cerebral Artery - diagnostic imaging ; Infarction, Middle Cerebral Artery - mortality ; Ischemia ; Ischemic stroke ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Patients ; Permeability ; Prognosis ; Prospective Studies ; ROC Curve ; Stroke ; Substance P ; Substance P - blood ; Tomography ; Tomography, X-Ray Computed ; Tumor necrosis factor-TNF ; Veins & arteries</subject><ispartof>Journal of critical care, 2020-06, Vol.57, p.1-4</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-d7f206c34fd7c0b69fed31cd5d99b0f3bc9fd5bc3c259a29e26e1586932c73053</citedby><cites>FETCH-LOGICAL-c384t-d7f206c34fd7c0b69fed31cd5d99b0f3bc9fd5bc3c259a29e26e1586932c73053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2425658805?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31991332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorente, Leonardo</creatorcontrib><creatorcontrib>Martín, María M.</creatorcontrib><creatorcontrib>Pérez-Cejas, Antonia</creatorcontrib><creatorcontrib>González-Rivero, Agustín F.</creatorcontrib><creatorcontrib>Argueso, Mónica</creatorcontrib><creatorcontrib>Ramos, Luis</creatorcontrib><creatorcontrib>Solé-Violán, Jordi</creatorcontrib><creatorcontrib>Cáceres, Juan J.</creatorcontrib><creatorcontrib>Jiménez, Alejandro</creatorcontrib><creatorcontrib>García-Marín, Victor</creatorcontrib><title>High serum substance P levels and mortality after malignant middle cerebral artery infarction</title><title>Journal of critical care</title><addtitle>J Crit Care</addtitle><description>Previously our team found higher serum substance P concentrations at day 1 of a malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving patients. Thus, the objective of this study was to determine whether serum substance P levels during the first week of MMCAI could predict mortality.
We included patients with MMCAI defined as computed tomography findings of acute infarction in at least of 50% of the territory and Glasgow Coma Scale ≤8. We determined serum concentrations of substance P on days 1, 4 and 8 of MMCAI. Thirty-day mortality was the study end-point.
Serum substance P concentrations at days 1 (p < .001), 4 (p < .001), and 8 (p = .001) of MMCAI in non-surviving (n = 34) were higher than in surviving patients (n = 34). Receiver operating characteristic analyses showed that serum substance P concentrations at days 1, 4, and 8 of MMCAI had an area under curve (95% confidence intervals) to predict 30-day mortality of 0.77 (0.66–0.87; p < .001), 0.82 (0.69–0.91; p < .001) and 0.85 (0.72–0.94; p < .001) respectively.
The two new findings of our study are that non-surviving MMCAI patients showed higher serum substance P levels at day 1, 4 and 8 than surviving, and that those levels could predict 30-day mortality.
•Serum substance P levels during the first week of a cerebral infarction were higher in non-surviving patients.•Serum substance Plevels during the first week of a cerebral infarctioncould predict early mortality.</description><subject>Aged</subject><subject>Blood platelets</subject><subject>Brain damage</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Critical care</subject><subject>Cytokines</subject><subject>Edema</subject><subject>Female</subject><subject>Glasgow Coma Scale</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infarction, Middle Cerebral Artery - blood</subject><subject>Infarction, Middle Cerebral Artery - diagnostic imaging</subject><subject>Infarction, Middle Cerebral Artery - mortality</subject><subject>Ischemia</subject><subject>Ischemic stroke</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Permeability</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>Stroke</subject><subject>Substance P</subject><subject>Substance P - 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Academic</collection><jtitle>Journal of critical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorente, Leonardo</au><au>Martín, María M.</au><au>Pérez-Cejas, Antonia</au><au>González-Rivero, Agustín F.</au><au>Argueso, Mónica</au><au>Ramos, Luis</au><au>Solé-Violán, Jordi</au><au>Cáceres, Juan J.</au><au>Jiménez, Alejandro</au><au>García-Marín, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High serum substance P levels and mortality after malignant middle cerebral artery infarction</atitle><jtitle>Journal of critical care</jtitle><addtitle>J Crit Care</addtitle><date>2020-06</date><risdate>2020</risdate><volume>57</volume><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>0883-9441</issn><eissn>1557-8615</eissn><abstract>Previously our team found higher serum substance P concentrations at day 1 of a malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving patients. Thus, the objective of this study was to determine whether serum substance P levels during the first week of MMCAI could predict mortality.
We included patients with MMCAI defined as computed tomography findings of acute infarction in at least of 50% of the territory and Glasgow Coma Scale ≤8. We determined serum concentrations of substance P on days 1, 4 and 8 of MMCAI. Thirty-day mortality was the study end-point.
Serum substance P concentrations at days 1 (p < .001), 4 (p < .001), and 8 (p = .001) of MMCAI in non-surviving (n = 34) were higher than in surviving patients (n = 34). Receiver operating characteristic analyses showed that serum substance P concentrations at days 1, 4, and 8 of MMCAI had an area under curve (95% confidence intervals) to predict 30-day mortality of 0.77 (0.66–0.87; p < .001), 0.82 (0.69–0.91; p < .001) and 0.85 (0.72–0.94; p < .001) respectively.
The two new findings of our study are that non-surviving MMCAI patients showed higher serum substance P levels at day 1, 4 and 8 than surviving, and that those levels could predict 30-day mortality.
•Serum substance P levels during the first week of a cerebral infarction were higher in non-surviving patients.•Serum substance Plevels during the first week of a cerebral infarctioncould predict early mortality.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31991332</pmid><doi>10.1016/j.jcrc.2020.01.022</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Aged Blood platelets Brain damage Chronic obstructive pulmonary disease Critical care Cytokines Edema Female Glasgow Coma Scale Humans Hypertension Infarction, Middle Cerebral Artery - blood Infarction, Middle Cerebral Artery - diagnostic imaging Infarction, Middle Cerebral Artery - mortality Ischemia Ischemic stroke Male Medical prognosis Middle Aged Mortality Patients Permeability Prognosis Prospective Studies ROC Curve Stroke Substance P Substance P - blood Tomography Tomography, X-Ray Computed Tumor necrosis factor-TNF Veins & arteries |
| title | High serum substance P levels and mortality after malignant middle cerebral artery infarction |
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