Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury

Mitochondrial fission factor (Mff) has been demonstrated to play a role in the activation of mitochondrial cleavage and mitochondrial death, denoting its role in the regulation of mitochondrial quality control. Recent evidence suggested that the mRNA translation of Mff is under the negative regulati...

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Veröffentlicht in:	Cell biology and toxicology 2020-08, Vol.36 (4), p.365-378
Hauptverfasser:	Wang, Jin, Zhu, Pingjun, Toan, Sam, Li, Ruibing, Ren, Jun, Zhou, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Acute Kidney Injury - metabolism Animal models Animals Biochemistry Biomedical and Life Sciences Cell Biology Cell death Homeostasis Inflammation Inflammatory response Injuries Ischemia Kidney - metabolism Kidneys Life Sciences Male Membrane Proteins - metabolism Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondrial Dynamics - physiology Mitochondrial Proteins - metabolism Mitophagy - physiology Mitosis Molecular modelling mRNA Original Article Oxidative stress Pharmacology/Toxicology Quality control Renal failure Renal tubules Restoration RNA-binding protein RNA-Binding Proteins - metabolism SIRT1 protein Up-Regulation
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