A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome

Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that are suggestive of humoral immunity impairment. Here, we sought to determine the follicular helper (Tfh) and follicular regulatory (Tfr) T cell profile in the blood of...

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Veröffentlicht in:	Journal of clinical immunology 2020-04, Vol.40 (3), p.447-455
Hauptverfasser:	Ottaviano, Giorgio, Gerosa, Jolanda, Santini, Micaela, De Leo, Pasqualina, Vecchione, Andrea, Jofra, Tatiana, Trimarchi, Cristiana, De Pellegrin, Maurizio, Agosti, Massimo, Aiuti, Alessandro, Marinoni, Maddalena, Cicalese, Maria Pia, Fousteri, Georgia
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Biomedical and Life Sciences Biomedicine Children CXCR3 protein Down syndrome Down's syndrome Genotype & phenotype Humoral immunity Immunology Infectious Diseases Internal Medicine Lymphocytes T Medical Microbiology Original Article PD-1 protein Phenotypes Respiratory tract diseases
Online-Zugang:	Volltext
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