Natural flavone tricetin suppresses oxidized LDL-induced endothelial inflammation mediated by Egr-1

•Tricetin prevented ox-LDL- induced expression of MCP-1, IL-1β and generation of ROS.•Tricetin inhibited attachment of U937 monocytes to HUVECs by ICAM-1 and VCAM-1.•Tricetin reduced ox-LDL- induced endothelial inflammation by inhibiting LOX-1/ERK1/2/Egr-1. Atherosclerosis is the primary cause of ma...

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Veröffentlicht in:	International immunopharmacology 2020-03, Vol.80, p.106224-106224, Article 106224
Hauptverfasser:	Cai, Luming, Zhang, Xuesong, Hou, Meiling, Gao, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Arteriosclerosis Atherosclerosis Cardiovascular diseases Cell adhesion Cell adhesion & migration Cell adhesion molecules Early growth response 1 (Egr-1) EGR-1 protein Endothelial cells Extracellular signal-regulated kinase Extracellular signal-regulated protein kinase (ERK1/2) Flavonoids IL-1β Inflammation Intercellular adhesion molecule 1 Interleukins Kinases Lectin-like oxidized LDL receptor-1 (LOX-1) Liquid oxygen Low density lipoprotein LOX-1 protein Monocyte chemoattractant protein 1 Monocytes oxidized LDL (ox-LDL) Protein kinase Proteins Reactive oxygen species Receptors Tricetin Vascular cell adhesion molecule 1
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