Effects of abdominal obesity on the association between air pollution and kidney function

Objectives This study aimed to evaluate the associations between ambient air pollutants, obesity, and kidney function. Subjects/methods We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollut...

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Veröffentlicht in:International Journal of Obesity 2020-07, Vol.44 (7), p.1568-1576
Hauptverfasser: Jeong, Su-Min, Park, Jin-Ho, Kim, Hyun-Jin, Kwon, Hyuktae, Hwang, Seo Eun
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container_end_page 1576
container_issue 7
container_start_page 1568
container_title International Journal of Obesity
container_volume 44
creator Jeong, Su-Min
Park, Jin-Ho
Kim, Hyun-Jin
Kwon, Hyuktae
Hwang, Seo Eun
description Objectives This study aimed to evaluate the associations between ambient air pollutants, obesity, and kidney function. Subjects/methods We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM 10 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and carbon monoxide (CO), in each subject’s residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function. Results High PM 10 , NO 2 , SO 2 , and CO concentrations were significantly associated with decreased kidney function ( β  = −2.39 and standard error = 0.32, −1.00 and 0.31, −1.23 and 0.28, and −1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM 10 , 1.42 vs 1.21 for SO 2 , and 1.27 vs 1.11 for CO). Conclusions Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. This may indicate a high susceptibility to air pollutants in obese people.
doi_str_mv 10.1038/s41366-020-0540-8
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Subjects/methods We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM 10 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and carbon monoxide (CO), in each subject’s residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function. Results High PM 10 , NO 2 , SO 2 , and CO concentrations were significantly associated with decreased kidney function ( β  = −2.39 and standard error = 0.32, −1.00 and 0.31, −1.23 and 0.28, and −1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM 10 , 1.42 vs 1.21 for SO 2 , and 1.27 vs 1.11 for CO). Conclusions Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. This may indicate a high susceptibility to air pollutants in obese people.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-020-0540-8</identifier><identifier>PMID: 31992841</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/1585 ; Abdomen ; Adipose tissue ; Adipose tissues ; Air pollution ; Analysis ; Body mass index ; Body size ; Carbon monoxide ; Chronic kidney failure ; Computed tomography ; Diameters ; Epidemiology ; Glomerular filtration rate ; Health Promotion and Disease Prevention ; Internal Medicine ; Kidney diseases ; Kidneys ; Medical colleges ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Nitrogen dioxide ; Obesity ; Particulate emissions ; Particulate matter ; Pollutants ; Public Health ; Residential areas ; Standard error ; Sulfur ; Sulfur compounds ; Sulfur dioxide</subject><ispartof>International Journal of Obesity, 2020-07, Vol.44 (7), p.1568-1576</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-25db8282abcc0074e35aca381f5da8903e0897e11f92b7486b412683b7212cb03</citedby><cites>FETCH-LOGICAL-c498t-25db8282abcc0074e35aca381f5da8903e0897e11f92b7486b412683b7212cb03</cites><orcidid>0000-0002-0312-3650 ; 0000-0002-3942-6813</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31992841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Su-Min</creatorcontrib><creatorcontrib>Park, Jin-Ho</creatorcontrib><creatorcontrib>Kim, Hyun-Jin</creatorcontrib><creatorcontrib>Kwon, Hyuktae</creatorcontrib><creatorcontrib>Hwang, Seo Eun</creatorcontrib><title>Effects of abdominal obesity on the association between air pollution and kidney function</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objectives This study aimed to evaluate the associations between ambient air pollutants, obesity, and kidney function. Subjects/methods We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM 10 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and carbon monoxide (CO), in each subject’s residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function. Results High PM 10 , NO 2 , SO 2 , and CO concentrations were significantly associated with decreased kidney function ( β  = −2.39 and standard error = 0.32, −1.00 and 0.31, −1.23 and 0.28, and −1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM 10 , 1.42 vs 1.21 for SO 2 , and 1.27 vs 1.11 for CO). Conclusions Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. 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Subjects/methods We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM 10 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and carbon monoxide (CO), in each subject’s residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function. Results High PM 10 , NO 2 , SO 2 , and CO concentrations were significantly associated with decreased kidney function ( β  = −2.39 and standard error = 0.32, −1.00 and 0.31, −1.23 and 0.28, and −1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM 10 , 1.42 vs 1.21 for SO 2 , and 1.27 vs 1.11 for CO). Conclusions Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. This may indicate a high susceptibility to air pollutants in obese people.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31992841</pmid><doi>10.1038/s41366-020-0540-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0312-3650</orcidid><orcidid>https://orcid.org/0000-0002-3942-6813</orcidid></addata></record>
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subjects 692/499
692/699/1585
Abdomen
Adipose tissue
Adipose tissues
Air pollution
Analysis
Body mass index
Body size
Carbon monoxide
Chronic kidney failure
Computed tomography
Diameters
Epidemiology
Glomerular filtration rate
Health Promotion and Disease Prevention
Internal Medicine
Kidney diseases
Kidneys
Medical colleges
Medicine
Medicine & Public Health
Metabolic Diseases
Nitrogen dioxide
Obesity
Particulate emissions
Particulate matter
Pollutants
Public Health
Residential areas
Standard error
Sulfur
Sulfur compounds
Sulfur dioxide
title Effects of abdominal obesity on the association between air pollution and kidney function
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