Pediatric hemispheric high-grade glioma: targeting the future
Pediatric high-grade gliomas (pHGGs) are a group of tumors affecting approximately 0.85 children per 100,000 annually. The general outcome for these tumors is poor with 5-year survival rates of less than 20%. It is now recognized that these tumors represent a heterogeneous group of tumors rather tha...
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| Veröffentlicht in: | Cancer and metastasis reviews 2020-03, Vol.39 (1), p.245-260 |
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| creator | Coleman, Christina Stoller, Schuyler Grotzer, Michael Stucklin, Ana Guerreiro Nazarian, Javad Mueller, Sabine |
| description | Pediatric high-grade gliomas (pHGGs) are a group of tumors affecting approximately 0.85 children per 100,000 annually. The general outcome for these tumors is poor with 5-year survival rates of less than 20%. It is now recognized that these tumors represent a heterogeneous group of tumors rather than one entity. Large-scale genomic analyses have led to a greater understanding of the molecular drivers of different subtypes of these tumors and have also aided in the development of subtype-specific therapies. For example, for pHGG with
NTRK
fusions, promising new targeted therapies are actively being explored. Herein, we review the clinico-pathologic and molecular classification of these tumors, historical treatments, current management strategies, and therapies currently under investigation. |
| doi_str_mv | 10.1007/s10555-020-09850-5 |
| format | Article |
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NTRK
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NTRK
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NTRK
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| subjects | Biomedical and Life Sciences Biomedicine Brain tumors Cancer Research Development and progression Genomic analysis Glioma Gliomas Oncology Pediatrics |
| title | Pediatric hemispheric high-grade glioma: targeting the future |
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